{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:41:59Z","timestamp":1777804919892,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    Children with neurofibromatosis type 1 have an increased incidence of optic pathway gliomas and central precocious puberty. This study explores whether the presence and location of optic pathway gliomas is associated with the changes in height and pubertal onset that are seen in these children. Retrospective analysis was undertaken of 75 individuals with a diagnosis of both neurofibromatosis type 1 and optic pathway gliomas, known to a single quaternary neurofibromatosis type 1 center, over a 20-year period. Central precocious puberty was more likely with optic pathway gliomas, observed in 28% of the cohort, and was associated with either optic chiasm involvement (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.046) or bilateral optic pathway gliomas (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001). This is presumably due to disruption in the hypothalamic-pituitary axis. Height standard deviation scores were not significantly different from the general population. Increased clinical monitoring of pubertal status is consequently required for children with neurofibromatosis type 1 and an optic pathway glioma.\n                  <\/jats:p>","DOI":"10.1177\/08830738251341591","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T03:41:18Z","timestamp":1748317278000},"page":"882-888","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Optic Pathway Gliomas on Puberty and Growth in Neurofibromatosis Type 1: A 20-Year Experience From a Tertiary Center"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6828-1956","authenticated-orcid":false,"given":"Robyn","family":"Haysom","sequence":"first","affiliation":[{"name":"University of Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-1614","authenticated-orcid":false,"given":"Amish","family":"Chinoy","sequence":"additional","affiliation":[{"name":"University of Manchester"},{"name":"Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"issue":"1","key":"e_1_3_2_2_2","first-page":"58","article-title":"Physical mapping of the von Recklinghausen neurofibromatosis region on chromosome 17","volume":"44","author":"Fountain JW","year":"1989","unstructured":"Fountain JW, Wallace MR, Brereton AM, et al. Physical mapping of the von Recklinghausen neurofibromatosis region on chromosome 17. Am J Hum Genet. 1989;44(1):58\u201367.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.11.704"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70063-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1579766"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21107"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-021-01170-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000144341.16830.01"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20160810-03"},{"issue":"2","key":"e_1_3_2_10_2","first-page":"289","article-title":"Growth and pubertal disorders in neurofibromatosis type 1","volume":"16","author":"Virdis R","year":"2003","unstructured":"Virdis R, Street ME, Bandello MA, et al. Growth and pubertal disorders in neurofibromatosis type 1. J Pediatr Endocrinol Metab. 2003;16(Suppl 2):289\u2013292.","journal-title":"J Pediatr Endocrinol Metab"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00380-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30279-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.12.933"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa138"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00418-0"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00339-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70449-3"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000458525"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-022-00411-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.100.4.667"},{"issue":"5","key":"e_1_3_2_21_2","first-page":"575","article-title":"National Institutes of Health Consensus Development Conference","volume":"45","author":"Neurofibromatosis. Conference statement","year":"1988","unstructured":"Neurofibromatosis. Conference statement. National Institutes of Health Consensus Development Conference. Arch Neurol. 1988;45(5):575\u2013578.","journal-title":"Arch Neurol"},{"key":"e_1_3_2_22_2","volume-title":"Is my study research?","author":"Council","year":"2022","unstructured":". Medical Research Council. Is my study research? NHS Health Research Authority. Published January 24, 2022. http:\/\/www.hra-decisiontools.org.uk\/research\/"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0012"},{"issue":"8229","key":"e_1_3_2_24_2","article-title":"Precocious puberty","volume":"368","author":"Bradley SH","year":"2020","unstructured":"Bradley SH, Lawrence N, Steele C, Mohamed Z. Precocious puberty. Br Med J. 2020;368(8229):l6597.","journal-title":"Br Med J."},{"issue":"1","key":"e_1_3_2_25_2","first-page":"841","article-title":"Neurofibromatosis type 1 and precocious puberty","volume":"13","author":"Virdis R","year":"2000","unstructured":"Virdis R, Sigorini M, Laiolo A, et al. Neurofibromatosis type 1 and precocious puberty. J Pediatr Endocrinol Metab. 2000;13(Suppl 1):841\u2013844.","journal-title":"J Pediatr Endocrinol Metab"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-022-02098-5"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.07.001"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr3710"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1783"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.12.933"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073818786807"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991203)87:4<317::AID-AJMG7>3.0.CO;2-X"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002728"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1159\/000182781"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738251341591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08830738251341591","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738251341591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:41:40Z","timestamp":1777495300000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08830738251341591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/08830738251341591"],"URL":"https:\/\/doi.org\/10.1177\/08830738251341591","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,27]]}}}