{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:08:03Z","timestamp":1787018883485,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the efficacy and safety of an updated institutional treatment protocol for convulsive status epilepticus (CSE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single-center, retrospective cohort study was designed to investigate the effectiveness of a protocolized approach for the treatment of pediatric convulsive status epilepticus. The revised Ege Pediatric Status Epilepticus Protocol (r-EPSEP) consists of first-line therapy (step 1 and step 2 with benzodiazepines), second-line therapy (step 3 and 4 with levetiracetam \/diphenylhydantoin \/ valproic acid), and third-line therapy (step 5 with midazolam infusion, and step 6 with propofol or thiopental sodium infusion). The success rates of each therapy line of the r-EPSEP were defined with clinical termination of convulsive status epilepticus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The convulsive status epilepticus cohort consisted of 293 children treated with the r-EPSEP. The cumulative success rates of each therapy line were as follows; first-line with 55.2%, second-line with 82.9%, and third-line with 96.9%. Benzodiazepine-resistant convulsive status epilepticus was defined in 131 children (44.7%) with convulsive status epilepticus. The r-EPSEP provided successful termination of refractory convulsive status epilepticus in 66 of 75 children (88%) with 3 therapy categorizations: (1) second-line therapy in 29 patients (38.6%), (2) midazolam infusion in 31 (41.3%), and (3) propofol or thiopental infusion in 6 (8%). Super-refractory convulsive status epilepticus evolved in 9 children (12%). A favorable neurologic outcome was defined in 74.7% of children with Modified Rankin Scores at the discharge time of children from the intensive care unit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The timeline-based protocol (r-EPSEP) provided considerable success rates in terminating status epilepticus episodes at predefined time points of each therapy line with a favorable early neurologic outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08830738251346214","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T06:18:33Z","timestamp":1750141113000},"page":"24-33","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety Study of the Revised Ege Pediatric Status Epilepticus Protocol (r-EPSEP)"],"prefix":"10.1177","volume":"41","author":[{"given":"Benay","family":"Turan","sequence":"first","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8738-1242","authenticated-orcid":false,"given":"Seda","family":"Kanmaz","sequence":"additional","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caner","family":"Turan","sequence":"additional","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u0131nar","family":"Yazici","sequence":"additional","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdem","family":"Sim\u015fek","sequence":"additional","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Yurtseven","sequence":"additional","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hepsen Mine","family":"Serin","sequence":"additional","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8719-0665","authenticated-orcid":false,"given":"Sanem","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gul","family":"Aktan","sequence":"additional","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarenur","family":"Gokben","sequence":"additional","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulent","family":"Karap\u0131nar","sequence":"additional","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eylem Ulas","family":"Saz","sequence":"additional","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Tekgul","sequence":"additional","affiliation":[{"name":"Ege University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2010.10.034"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535759719868180"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.5698\/1535-7597-16.1.48"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/EPI.12074"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.SEIZURE.2015.04.002"},{"key":"e_1_3_2_8_2","unstructured":"Advanced paediatric life support: a practical approach [Kap. 1-25 og Appendix A-G]. 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