{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:42:43Z","timestamp":1777804963622,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Spinal muscular atrophy (SMA) is a progressive neuromuscular disorder caused by mutations in the\n                    <jats:italic toggle=\"yes\">SMN1<\/jats:italic>\n                    gene, leading to motor neuron degeneration. This report presents a case of a 22-day-old infant with spinal muscular atrophy who was found to have elevated troponin I level in preparation for administration of a gene therapy with known cardiac adverse effects. Although initial echocardiogram revealed a left-ventricular ejection fraction of 57% at 22 days old, subsequent comprehensive cardiac evaluation revealed improving troponin I levels with a normal left-ventricular ejection fraction of 70% at 34 days of life prior to starting gene therapy. Although not common, elevated troponin I level in an otherwise asymptomatic newborn can be seen in spinal muscular atrophy. This case underscores that elevated troponins may be intrinsic to newborns with spinal muscular atrophy even before starting therapies for spinal muscular atrophy. In addition, we illustrate no further cardiac abnormalities after infusion of the aforementioned gene therapy in a child with asymptomatic elevated troponin I after cardiac clearance.\n                  <\/jats:p>","DOI":"10.1177\/08830738251351818","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T08:17:16Z","timestamp":1752221836000},"page":"105-108","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Troponin in an Infant With Spinal Muscular Atrophy"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-4893","authenticated-orcid":false,"given":"Richelle L.","family":"Homo","sequence":"first","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Brooke Army Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratik","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHRISTUS Children's Hospital, San Antonio, TX, USA"},{"name":"Department of Pediatrics, Baylor College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Govinda","family":"Paudel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHRISTUS Children's Hospital, San Antonio, TX, USA"},{"name":"Department of Pediatrics, Baylor College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa D.","family":"Svoboda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHRISTUS Children's Hospital, San Antonio, TX, USA"},{"name":"Department of Pediatrics, Baylor College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-71"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-023-01320-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-2448-0330"},{"key":"e_1_3_2_5_2","first-page":"14:1188330","article-title":"Cardiovascular involvement in Epstein\u2013Barr virus infection","author":"Chen X","year":"2023","unstructured":"Chen X, Li Y, Deng L, et al. Cardiovascular involvement in Epstein\u2013Barr virus infection. Front Immunol. 2023;14:1188330. doi:https:\/\/doi.org\/10.3389\/fimmu.2023.1188330","journal-title":"Front Immunol"},{"key":"e_1_3_2_6_2","unstructured":"Ace O Domb S Fcfp C. Myocarditis as the Initial Presentation of Epstein-Barr Virus Infection in a 17-Year-Old Male Patient. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539739\/."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0298609"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57185-w"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2018.06.313"},{"key":"e_1_3_2_10_2","first-page":"11:1259293","article-title":"High-sensitive cardiac troponin I (hs-cTnI) concentrations in newborns diagnosed with spinal muscular atrophy","author":"Johannsen J","year":"2023","unstructured":"Johannsen J, Weiss D, Driemeyer J, et al. High-sensitive cardiac troponin I (hs-cTnI) concentrations in newborns diagnosed with spinal muscular atrophy. Front Pediatr. 2023;11:1259293. doi:https:\/\/doi.org\/10.3389\/fped.2023.1259293","journal-title":"Front Pediatr"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738251351818","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08830738251351818","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738251351818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:41:47Z","timestamp":1777495307000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08830738251351818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/08830738251351818"],"URL":"https:\/\/doi.org\/10.1177\/08830738251351818","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,11]]}}}