{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:30:14Z","timestamp":1781332214892,"version":"3.54.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    Infantile epileptic spasms syndrome carries high morbidity and mortality compared with other childhood epilepsy syndromes. High-dose prednisolone is considered the first-line option by many neurologists, with efficacy comparable to adrenocorticotropic hormone (ACTH).\u202f The second-line therapy is debated if prednisolone fails to induce remission. The objective of this study was to evaluate the efficacy of adrenocorticotropic hormone versus vigabatrin as second-line antiseizure medication in patients with infantile epileptic spasms syndrome after high-dose prednisolone failure. Thirty-eight patients met the inclusion criteria. Seventeen patients (45%) took vigabatrin and 21 (55%) took adrenocorticotropic hormone. There were no significant differences regarding age of infantile spasms onset (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.37) or sex between both groups (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.32). Complete control of epileptic spasms was seen in 5 of 17 patients (29.5%) taking vigabatrin and in 4 of 21\u202f(19%) taking adrenocorticotropic hormone (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.70). Vigabatrin showed higher efficacy; however, it did not reach statistical significance, possibly because of our sample size. These results may help guide family counseling after the failure of high-dose prednisolone as first-line therapy.\n                  <\/jats:p>","DOI":"10.1177\/08830738251361701","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T06:06:21Z","timestamp":1754287581000},"page":"359-364","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Vigabatrin Versus Adrenocorticotropic Hormone After High-Dose Prednisolone Failure for the Treatment of Epileptic Spasms"],"prefix":"10.1177","volume":"41","author":[{"given":"Austin","family":"Layton","sequence":"first","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifteh","family":"Sattar","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong M.","family":"Rho","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Gold","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zimbric","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Bui","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Sahagian","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Kim-McManus","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4389-9792","authenticated-orcid":false,"given":"Aliya","family":"Frederick","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Guido-Estrada","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuja","family":"Jindal","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Wiegand","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Dove","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Sweat","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Nespeca","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-2774","authenticated-orcid":false,"given":"Maria A.","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Rady Children's Hospital"},{"name":"University of California San Diego"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,3]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"130","article-title":"A propos de 21 cas d'hypsarhythmia de Gibbs; son traitement spectaculaire par l'ACTH","volume":"58","author":"Sorel L","year":"1958","unstructured":"Sorel L, Dusaucy-Bauloye A. 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