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This study quantifies the gait characteristics of 22 females with Rett syndrome (divided into 3 age groups) and compares them with age-matched neurotypical females. Bilateral sagittal plane joint angles of the hip, knee, and ankle were analyzed. Measures included joint range of motion, stride time, peak angular velocity, angle-angle diagrams, phase portrait areas, and asymmetries. Results revealed reduced joint range of motion and angular velocity in individuals with Rett syndrome, as well as greater asymmetries in gait parameters reflecting disruptions in bilateral coordination. Phase portraits and angle-angle diagrams indicated preserved coordination in proximal joints but greater variability at the ankle. Ankle movement in individuals with Rett syndrome aged 9-14 years showed a closer resemblance to Controls. These findings identify underlying lower limb motion patterns that contribute to gait deficits in Rett syndrome, guiding future targeted interventions to improve their mobility.<\/jats:p>","DOI":"10.1177\/08830738251371586","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T18:36:56Z","timestamp":1758307016000},"page":"647-665","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gait Analysis in Rett Syndrome: Integrating Linear and Nonlinear Techniques"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2539-7585","authenticated-orcid":false,"given":"Dacia","family":"Martinez Diaz","sequence":"first","affiliation":[{"name":"University of Houston"},{"name":"University of Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brock","family":"Futrell","sequence":"additional","affiliation":[{"name":"University of Houston"},{"name":"University of Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Suter","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital"},{"name":"Baylor College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-9896","authenticated-orcid":false,"given":"Charles S.","family":"Layne","sequence":"additional","affiliation":[{"name":"University of Houston"},{"name":"University of Houston"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-023-02169-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22124"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/15748847113086660069"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2014.993436"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-015-0353-y"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0387-7604(12)80201-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/s0012162203000616"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1104575"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147555"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0387-7604(12)80170-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000337637"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2019.1674389"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22115"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2018.08.010"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2020.1820084"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073818780471"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1515\/ijdhd-2012-0020"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37500"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1172805"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02398-1"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0966-6362(98)00014-9"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/app12147223"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(94)90199-6"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22124"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2023.109142"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2024.110230"},{"issue":"1","key":"e_1_3_3_28_2","first-page":"1","article-title":"Methodologies to objectively assess gait and postural control features in Rett syndrome: with a comment on specific challenges and how to address them","volume":"4","author":"Layne CS","year":"2017","unstructured":"Layne CS, Lee BC, Young D, Glaze DG, Suter B. 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