{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:00:49Z","timestamp":1785578449718,"version":"3.56.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Autoimmune encephalitis in children is a severe immune-mediated disorder with significant neuropsychiatric manifestations and long-term morbidity. Despite advances in immunotherapy, poor short-term prognosis remains a challenge, necessitating identification of prognostic factors for optimized interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analysed 96 pediatric autoimmune encephalitis patients from a single center. Demographic, clinical, and laboratory data were compared between good (n\u2009=\u200960) and poor (n\u2009=\u200936) prognosis groups. Statistical analyses included univariate tests, multivariate logistic regression, and receiver operating characteristic curve evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Univariate analysis identified autonomic symptoms, status epilepticus, impaired consciousness, infection, fever, abnormal MRI, and elevated cerebrospinal fluid cell counts as significant predictors. Multivariate analysis confirmed MRI abnormalities (odds ratio [OR]\u2009=\u20094.39), infection (OR\u2009=\u20093.03), autonomic symptoms (OR\u2009=\u20094.09), disorders of consciousness (OR\u2009=\u20094.29), and fever (OR\u2009=\u20093.69) as risk factors. The combined receiver operating characteristic model achieved an area under the curve of 0.816 (sensitivity 72.22%, specificity 83.33%), outperforming individual predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multivariate analysis identified abnormal MRI findings, infections, fever, autonomic symptoms, and impaired consciousness as independent predictors of poor short-term prognosis in children with autoimmune encephalitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08830738251396175","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T18:23:31Z","timestamp":1767637411000},"page":"1152-1162","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multivariate Risk-Factor Analysis of Short-Term Poor Prognosis in Children With Autoimmune Encephalitis"],"prefix":"10.1177","volume":"41","author":[{"given":"Ruirui","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Pediatric Internal Medicine, The Second Qilu Hospital of Shandong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Internal Medicine, The Second Qilu Hospital of Shandong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5496-3796","authenticated-orcid":false,"given":"Meiyan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Internal Medicine, The Second Qilu Hospital of Shandong University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073820923834"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2020.09.011"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.22159\/ijms.2023.v11i1.47041"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/jpn.JPN_185_16"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.952317","article-title":"Evaluation of multiple consensus criteria for autoimmune encephalitis and temporal analysis of symptoms in a pediatric encephalitis cohort","volume":"13","author":"Pointon T","year":"2022","unstructured":"Pointon T, Ward R, Yeshokumar A, Piquet A, Schreiner T, Kammeyer R. 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