{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:07:54Z","timestamp":1779188874790,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To elucidate factors associated with epilepsy in children with septo-optic dysplasia (SOD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Patients (&lt;21 years) diagnosed with SOD (2013-2023) were identified. Multivariate binomial regression predicted seizures in patients with SOD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 107 children (M:F\u2009=\u200946:61) with SOD. Among those, 103 had seizure data. Fifty-two (52\/103; 50.5%) experienced seizures. Median age of seizure onset was 9 months (IQR: 4\u2005months \u22122 years 5\u2005months). Abnormal neurologic examinations were seen in 82.6% with seizures (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.002). Global developmental delay was noted in 46 (43.0%) and associated with seizures (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.004). Of 24 patients with autism spectrum disorder, 75% had seizures (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.01). Ventriculomegaly and schizencephaly were associated with seizures (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.015,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.004). No significant associations were found between seizures and SOD diagnostic criteria combinations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Seizures are highly prevalent in SOD patients. Diagnostic criteria for SOD do not predict seizures, underscoring the need for comprehensive screening in all SOD patients, irrespective of phenotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08830738261420288","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:34:50Z","timestamp":1773254090000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Seizure Development in Septo-optic Dysplasia: A Retrospective Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-8567","authenticated-orcid":false,"given":"Megana","family":"Iyer","sequence":"first","affiliation":[{"name":"University of Louisville School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grae","family":"McCarty","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Kluthe","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Danieli","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine"},{"name":"University of Louisville School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9516-2285","authenticated-orcid":false,"given":"Cemal","family":"Karakas","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine"},{"name":"University of Louisville School of Medicine"},{"name":"Norton Neuroscience Institute"},{"name":"Children's National"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Singer","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine"},{"name":"University of Louisville School of Medicine"},{"name":"Norton Neuroscience 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