{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:25:25Z","timestamp":1787646325411,"version":"build-2736575974"},"reference-count":72,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"ESDC Summer Studentship"},{"name":"Dr. Peter Humphreys Summer Studentship in Neuroscience Research"},{"name":"CHEO RI Summer Studentship"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"abstract":"<jats:p>\n                    This pilot randomized-controlled trial aimed to evaluate the impact of aerobic exercise on (1) headache-related disability, via the Pediatric Migraine Disability Assessment Scale, and (2) quality of life, via the Pediatric Quality of Life Inventory and KIDSCREEN-27. Participants (8-17 years of age) were randomized at an initial 1:1 ratio revised to 2:1 to a 4-week at-home program of daily aerobic exercise or stretching. Nineteen participants (89% female, mean age\u2009=\u200914.3\u2009\u00b1\u20092.2 years) completed the study. There were clinically meaningful differences in headache-related disability in both groups from baseline to post-study (standardized mean change, Hedges\u2019 g, in aerobic exercise group: 0.53 [95% CI: \u22120.29, 1.35]; stretching group: 0.71 [95% CI: \u22120.27, 1.66]), but no differences in quality of life (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    values ranging from 0.06 to 1.00 across all domains). When considered alongside the broader health benefits of exercise documented elsewhere, our findings represent a preliminary signal warranting further investigation of exercise training as a potential care pathway for pediatric headache. Given our limited sample size, these findings should be interpreted with caution, and alone are insufficient to inform clinical recommendations. This study was limited by poor enrollment over 5 years and higher rates of drop-out in the aerobic exercise group. Future studies should seek to define and overcome feasibility barriers associated with exercise-based interventions.\n                  <\/jats:p>","DOI":"10.1177\/08830738261476485","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:45:09Z","timestamp":1787381109000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of Aerobic Exercise on Pediatric Headache-Related Disability and Quality of Life: A Pilot Randomized Controlled Trial"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-1797","authenticated-orcid":false,"given":"Erin","family":"Artna","sequence":"first","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute"},{"name":"Temerty Faculty of Medicine, University of Toronto, Toronto, Canada"},{"name":"Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Reddy","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitty","family":"Chen","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia E.","family":"Longmuir","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute"},{"name":"Faculty of Medicine, University of Ottawa, Ottawa, Canada"},{"name":"Faculty of Health Sciences, University of Ottawa, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-7210","authenticated-orcid":false,"given":"Daniela","family":"Pohl","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute"},{"name":"Faculty of Medicine, University of Ottawa, Ottawa, Canada"},{"name":"Division of Neurology, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.8.797"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03793.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00680.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00681.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00372.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01288.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2017.01.002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01774.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756285615616586"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/life13030825"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008095"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01410.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.282533"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-025-00722-5"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12738"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00624.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1191\/0269215503cr657oa"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.4397"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2013.12.010"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S159622"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2017.06.009"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.4103\/jod.jod_74_24"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1555029"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1992.hed3201050.x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2002.02202.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200209010-00004"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.03.031"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417752119"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-024-03660-2"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100008295"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411419681"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.11.2034"},{"key":"e_1_3_3_35_2","unstructured":"Lane K Education E Copeland J. Get active questionnaire. Published 2017. https:\/\/www.centre4activeliving.ca\/news\/2017\/11\/get-active-questionnaire\/"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/02701367.2010.10599707"},{"key":"e_1_3_3_37_2","unstructured":"Migraine Buddy. Accessed September 9 2025. https:\/\/migrainebuddy.com\/"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199902000-00003"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150545"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-461"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-023-02759-y"},{"key":"e_1_3_3_44_2","unstructured":"Office of the Premier. Ontario moving to next phase of reopening on February 17. 2022. Accessed May 1 2026. https:\/\/news.ontario.ca\/en\/release\/1001600\/ontario-moving-to-next-phase-of-reopening-on-february-17"},{"key":"e_1_3_3_45_2","unstructured":"Dekker J Macdonald R. COVID-19 restrictions index update. Government of Canada. 2022. Accessed May 1 2026. https:\/\/www150.statcan.gc.ca\/n1\/pub\/36-28-0001\/2022008\/article\/00002-eng.htm"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-022-01503-y"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20140148"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12204"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-010-9223-3"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100002869"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2003.03087.x"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.06.040"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01752.x"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-66"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1177\/009286150203600127"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1684\/mrh.2018.0431"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2504546"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738231170067"},{"key":"e_1_3_3_59_2","unstructured":"Efficacy and safety of erenumab in pediatric subjects with chronic migraine (OASIS(CM)). ClinicalTrials.gov. Accessed May 20 2026. https:\/\/clinicaltrials.gov\/study\/NCT03832998?rank=1&tab=study"},{"key":"e_1_3_3_60_2","unstructured":"A study to test if fremanezumab is effective in preventing migraine in children and adolescents. ClinicalTrials.gov. Accessed May 20 2026. https:\/\/clinicaltrials.gov\/study\/NCT04530110?tab=study&a=34"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175806"},{"key":"e_1_3_3_62_2","unstructured":"Statistics Canada. Physical activity and screen time among Canadian children and youth 2016 and 2017. https:\/\/www150.statcan.gc.ca\/n1\/pub\/82-625-x\/2019001\/article\/00003-eng.htm"},{"issue":"3","key":"e_1_3_3_63_2","first-page":"343","article-title":"Migraine & paediatric obesity: a plausible link?","volume":"139","author":"Ravid S","year":"2014","unstructured":"Ravid S. Migraine & paediatric obesity: a plausible link? Indian J Med Res. 2014;139(3):343-348.","journal-title":"Indian J Med Res"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.4278\/0890-1171-12.1.38"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-020-04551-x"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13023"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2024-002024"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20021263"},{"issue":"3","key":"e_1_3_3_69_2","first-page":"84","article-title":"The prevalence and characteristics of migraine among the Belgian working population","volume":"107","author":"Moens G","year":"2007","unstructured":"Moens G, Johannik K, Verbeek C, Bulterys S. The prevalence and characteristics of migraine among the Belgian working population. Acta Neurol Belg. 2007;107(3):84-90.","journal-title":"Acta Neurol Belg"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2023.01.002"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00613.x"},{"key":"e_1_3_3_72_2","unstructured":"Statistics Canada. Youth\u2014but not adults\u2014reported less physical activity during the COVID-19 pandemic. https:\/\/www150.statcan.gc.ca\/n1\/pub\/45-28-0001\/2021001\/article\/00032-eng.htm"},{"key":"e_1_3_3_73_2","unstructured":"Pediatric migraine frequency increased during COVID-19 pandemic. 2020. Accessed September 19 2025. https:\/\/practicalneurology.com\/news\/pediatric-migraine-frequency-increased-during-covid-19-pandemic"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738261476485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08830738261476485","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738261476485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:52:21Z","timestamp":1787644341000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08830738261476485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":72,"alternative-id":["10.1177\/08830738261476485"],"URL":"https:\/\/doi.org\/10.1177\/08830738261476485","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]},"article-number":"08830738261476485"}}