{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:16:30Z","timestamp":1777803390033,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1987,10,1]],"date-time":"1987-10-01T00:00:00Z","timestamp":560044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:p>Despite the immaturity of the newborn brain, the neonatal period is reported to have a very high frequency of seizures. This review concludes that many of the neonatal events that are called seizures probably originate from subcortical structures, have little in common with cortical seizures seen in older individuals, and may not benefit from conventional anticonvulsant treatment. Many studies of anticonvulsants in the newborn have important methodologic problems, compounded by the fact that the seizures tend to spontaneously remit with the resolution of the acute hypoxic-ischemic encephalopathy that is most often the cause. Randomized trials of anticonvulsants in this setting have not been carried out. Even if many of these seizures do not originate in the cortex, they still imply profound cortical disturbance and are associated with high mortality and morbidity. It is unknown if the type and duration of treatment influence the long-term, overall outcome. The seizures usually stop in the newborn period, and anticonvulsants beyond hospital discharge seem unwarranted because they are unlikely to prevent subsequent epilepsy. Newer investigations, including video-EEG and nuclear magnetic resonance studies, may clarify the real significance of neonatal seizures. ( J Child Neurol 1987;2:244-51).<\/jats:p>","DOI":"10.1177\/088307388700200402","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T15:05:50Z","timestamp":1253027150000},"page":"244-251","source":"Crossref","is-referenced-by-count":23,"title":["Neonatal Seizures"],"prefix":"10.1177","volume":"2","author":[{"given":"Peter R.","family":"Camfield","sequence":"first","affiliation":[{"name":"Izaak Walton Killam Hospital for Children, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol S.","family":"Camfield","sequence":"additional","affiliation":[{"name":"Izaak Walton Killam Hospital for Children, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,10,1]]},"reference":[{"key":"atypb1","first-page":"54","volume":"6","author":"Bergman I.","year":"1982","journal-title":"Semin Perinatol"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)34971-9"},{"key":"atypb3","unstructured":"Volpe J.: Neonatal seizures, in Neurology of the Newborn. Philadelphia, WB Saunders, 1981, pp 111-140."},{"key":"atypb4","unstructured":"Lombroso CT: Prognosis in neonatal seizures, in Delgado-Escueta A, Wasterlain C, Treiman D, Porter R (eds): Status Epilepticus. Advances in Neurology, vol 34. New York, Raven Press, 1983, pp 101-113."},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80348-4"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1986.tb03914.x"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1542\/peds.70.2.165","volume":"70","author":"Holden KR","year":"1982","journal-title":"Pediatrics"},{"key":"atypb8","unstructured":"Brown AW: Factors during neonatal life that influence brain disorders, in Freeman JM (ed): Prenatal & Perinatal Factors Associated With Brain Disorders. NIH Publication No. 85-1149, 1985, pp 263-358."},{"key":"atypb9","first-page":"93","volume":"34","author":"Kellaway P.","year":"1983","journal-title":"Advances in Neurology"},{"key":"atypb10","first-page":"601","volume":"139","author":"Clancy R.","year":"1985","journal-title":"Am J Dis Child"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170411"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060090096024"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520030056014"},{"key":"atypb14","volume-title":"Paroxsymal activity in EEG of normal children","author":"Petersen I.","year":"1968"},{"key":"atypb15","first-page":"31","volume":"1","author":"Tharp B.","year":"1981","journal-title":"Neurology"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1059581"},{"key":"atypb17","volume-title":"Bickford R: Atlas of Neonatal Electroencephalography","author":"Werner S.","year":"1977"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1985.tb10024.x"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500180075017"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140607"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.10.975"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490250056006"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200412"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500120025004"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198510000-00005"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150111"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100046771"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1159\/000240998"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090612"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(75)90083-7"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.11.1445"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80034-1"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.12.1401"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1986.02140240088032"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.1.108"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197308232890807"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80713-2"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80575-0"},{"key":"atypb39","first-page":"21","volume":"137","author":"Finer NN","year":"1983","journal-title":"Am J Dis Child"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80027-9"},{"key":"atypb41","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1542\/peds.45.3.404","volume":"45","author":"Rose AL","year":"1970","journal-title":"Pediatrics"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(85)90030-6"},{"key":"atypb43","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0370-4475(77)80021-X","volume":"7","author":"Tharpe B.","year":"1977","journal-title":"Rev Electroencephalogr Neurophysiol Clin"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500100030012"},{"key":"atypb45","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1469-8749.1980.tb04382.x","volume":"22","author":"Tibbles JA","year":"1980","journal-title":"Dev Med Child Neurol"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1985.tb03426.x"},{"key":"atypb47","first-page":"649","volume":"3","author":"Labrecque D.","year":"1984","journal-title":"Clin Pharm"},{"key":"atypb48","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/ana.410150620","volume":"15","author":"Bergman I.","year":"1984","journal-title":"Ann Neurol"},{"key":"atypb49","first-page":"716","volume":"14","author":"Vining E.","year":"1985","journal-title":"Pediatr Ann"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088307388700200402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088307388700200402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:36:06Z","timestamp":1777494966000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/088307388700200402"}},"subtitle":["A Commentary on Selected Aspects"],"short-title":[],"issued":{"date-parts":[[1987,10]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,10]]}},"alternative-id":["10.1177\/088307388700200402"],"URL":"https:\/\/doi.org\/10.1177\/088307388700200402","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,10]]}}}