{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:16:28Z","timestamp":1777803388623,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1987,10,1]],"date-time":"1987-10-01T00:00:00Z","timestamp":560044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:p>The clinical and autopsy findings on a 6-year-old child presenting with 11 episodes of relapsing neurological symptoms since age 10 months are reported. The brain showed multiple and irregular demyelinative lesions in the cerebral and cerebellar white matter as well as in the tegmentum and base of the brain stem. This case reconfirms the existence of typical multiple sclerosis (MS) in childhood, beginning even in infancy. In addition, elevated Epstein-Barr virus antibody titers during the clinical course of this patient raise an interesting but still speculative etiological possibility for MS. ( J Child Neurol 1987;2:252-256).<\/jats:p>","DOI":"10.1177\/088307388700200403","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T15:05:50Z","timestamp":1253027150000},"page":"252-256","source":"Crossref","is-referenced-by-count":53,"title":["Multiple Sclerosis Beginning in Infancy"],"prefix":"10.1177","volume":"2","author":[{"given":"Cheng-Mei","family":"Shaw","sequence":"first","affiliation":[{"name":"Department of Pathology, Child Development and Mental Retardation Center, University of Washington School of Medicine, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Ellsworth C.","family":"Alvord","sequence":"additional","affiliation":[{"name":"Department of Pathology, Child Development and Mental Retardation Center, University of Washington School of Medicine, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1987,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1970.tb05807.x"},{"key":"atypb2","unstructured":"Shaw CM, Alvord EC Jr: Treatment of experimental allergic encephalomyelitis in monkeys. II. Histopathological studies, in Shiraki H, Yonezawa T, Kuroiwa Y (eds): The Aetiology and Pathogenesis of the Demyelinating Diseases . Tokyo, Japan Science Press, 1976, pp 377-395."},{"key":"atypb3","doi-asserted-by":"crossref","unstructured":"Shaw CM, Alvord EC Jr: A morphologic comparison of three experimental models of experimental allergic encephalomyelitis with multiple sclerosis, in Alvord EC Jr, Kies MW, Suckling AJ (eds): Experimental Allergic Encephalomyelitis, A Useful Model for Multiple Sclerosis. New York, Alan R Liss Inc, 1984, pp 61-66.","DOI":"10.1007\/978-1-4613-2403-4_3"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1922.02190130062009"},{"key":"atypb5","unstructured":"Nielsen JM: A Textbook of Clinical Neurology, ed 3. New York, Hoeber, 1951, p 536."},{"key":"atypb6","first-page":"904","volume":"24","author":"Oppenheim H.","year":"1887","journal-title":"Berl Klin Wochenschr"},{"key":"atypb7","first-page":"37","volume":"13","author":"Gaelinger MH","year":"1909","journal-title":"\u00c9cho m\u00e9d du Nord Lille"},{"key":"atypb8","unstructured":"Wilson SAK, in Bruce AN (ed): Neurology, ed 2. Baltimore, Williams and Wilkins, 1955, vol 1, pp 172-173."},{"key":"atypb9","first-page":"2632","volume":"62","author":"Nobel E.","year":"1912","journal-title":"Wien med Wochenschr"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1059641"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050190087021"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1007\/BF01882681"},{"key":"atypb13","first-page":"410","volume":"17","author":"Schlesinger H.","year":"1908","journal-title":"Arbeiten a d Neurol Inst Wien"},{"key":"atypb14","first-page":"796","volume":"59","author":"Arnouts Ch","year":"1959","journal-title":"Acta Neurol Psychiatr Belg"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196509302731410"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-75-4-579"},{"key":"atypb17","unstructured":"Alvord EC Jr: Disseminated encephalomyelitis: Its variations in form and their relationships to other diseases of the nervous system, in Vinken PJ, Bruyn GW, Klawans HL (eds): Handbook of Clinical Neurology. Amsterdam and New York, Elsevier Science, 1985, vol 3, pp 467-502."}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088307388700200403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088307388700200403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:36:06Z","timestamp":1777494966000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/088307388700200403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,10]]}},"alternative-id":["10.1177\/088307388700200403"],"URL":"https:\/\/doi.org\/10.1177\/088307388700200403","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,10]]}}}