{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:22:40Z","timestamp":1790022160372,"version":"4.0.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1989,4,1]],"date-time":"1989-04-01T00:00:00Z","timestamp":607392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:p>\n                    Chronically meconium-stained fetuses may ultimately suffer cerebral palsy and other devastation. The mechanism is unknown. Innocuous pregnancy complications may cause some fetuses to discharge meconium, which may become hazardous, independently of aspiration. We herein report previously undescribed, meconium-induced umbilical and placental vascular necrosis. To investigate whether meconium causes vasocontraction, we tested umbilical vein tissue with an isometric transducer connected to a polygraph. The specimens were suspended in a 30-mL organ bath with Krebs solution (pH, 7.4; temperature, 37\u00b0C; under aeration with 95% O\n                    <jats:sub>2<\/jats:sub>\n                    and 5% CO\n                    <jats:sub>2<\/jats:sub>\n                    ). We exposed the tissue to meconium and compared meconium-induced vasocontraction with that induced by Krebs solution and 10\n                    <jats:sup>-5<\/jats:sup>\n                    molar serotonin. Meconium maximally produced 62.9% of serotonin-induced vasocontraction. Krebs solution and boiled meconium did not produce vasocontraction. We hypothesize that meconium may cause placental and umbilical cord vasocontraction, cerebral and other fetal hypoperfusion, and major poor outcome. ( J Child Neurol 1989;4:137-142).\n                  <\/jats:p>","DOI":"10.1177\/088307388900400214","type":"journal-article","created":{"date-parts":[[2009,9,15]],"date-time":"2009-09-15T15:05:50Z","timestamp":1253027150000},"page":"137-142","source":"Crossref","is-referenced-by-count":133,"title":["Meconium-Induced Vasocontraction: A Potential Cause of Cerebral and Other Fetal Hypoperfusion and of Poor Pregnancy Outcome"],"prefix":"10.1177","volume":"4","author":[{"given":"Geoffrey","family":"Altshuler","sequence":"first","affiliation":[{"name":"Departments of Pathology and Microbiology, the University of Oklahoma Health Sciences Center, Oklahoma City, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Hyde","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Microbiology, the University of Oklahoma Health Sciences Center, Oklahoma City, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1989,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1542\/peds.82.2.240","volume":"82","author":"Freeman JM","year":"1988","journal-title":"Pediatrics"},{"key":"atypb2","unstructured":"Altshuler G.: The placenta, how to examine it, its normal growth and development , in Naeye RL, Kissane JM, Kaufman N (eds): Perinatal Diseases IAP Monograph. Baltimore, Williams & Wilkins, 1981, pp 5-22."},{"key":"atypb3","first-page":"459","volume":"66","author":"Miller PW","year":"1985","journal-title":"Obstet Gynecol"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80239-3"},{"key":"atypb5","unstructured":"Luna LG (ed): Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology , ed 3. New York, McGraw Hill, 1968, p 74."},{"key":"atypb6","author":"Hyde S.","journal-title":"Obstet Gynecol"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1159\/000298881"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(74)90119-1"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1968.tb00703.x"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1139\/y72-001"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1972.222.2.345"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(72)90006-4"},{"key":"atypb13","volume-title":"The Collaborative Perinatal Study of the National Institute of Neurological Diseases and Stroke. The Women and Their Pregnancies","author":"Niswander KR","year":"1972"},{"key":"atypb14","unstructured":"Freeman JM (ed): Prenatal and Perinatal Factors Associated with Brain Disorders. National Institutes of Health Publication No. (NIH) 85-1149, 1985."},{"key":"atypb15","volume-title":"The medicolegal imperative: Placental pathology and epidemiology","author":"Altshuler G."}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088307388900400214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088307388900400214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:38:05Z","timestamp":1777495085000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/088307388900400214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,4]]}},"alternative-id":["10.1177\/088307388900400214"],"URL":"https:\/\/doi.org\/10.1177\/088307388900400214","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4]]}}}