{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:32:09Z","timestamp":1777804329887,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1991,7,1]],"date-time":"1991-07-01T00:00:00Z","timestamp":678326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:p>\n                    Positron emission tomography was performed on six patients with Rett syndrome to investigate cerebral blood flow and oxygen metabolism, and the results were compared with the concurrent clinical status of the patients. The cerebral metabolic rate of oxygen (CMRO\n                    <jats:sub>2<\/jats:sub>\n                    ) was low in five patients, and oxygen extraction fraction was low in four patients; both had a tendency to decline with advancing age. Although the cause is unknown, it is suggested that impaired oxidative metabolism exists in Rett syndrome. An analysis of the distribution among brain regions showed that the ratios of values for the frontal cortex to those for the temporal cortex for both cerebral blood flow and CMRO\n                    <jats:sub>2<\/jats:sub>\n                    were lower than those for the controls, which may indicate the loss of hyperfrontality in Rett syndrome. (J Child Neurol 1991;6:237-242).\n                  <\/jats:p>","DOI":"10.1177\/088307389100600306","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T02:13:25Z","timestamp":1230084805000},"page":"237-242","source":"Crossref","is-referenced-by-count":14,"title":["Cerebral Blood Flow and Oxygen Metabolism in Rett Syndrome"],"prefix":"10.1177","volume":"6","author":[{"given":"Hideto","family":"Yoshikawa","sequence":"first","affiliation":[{"name":"Division of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Fueki","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisaharu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Sakuragawa","sequence":"additional","affiliation":[{"name":"Division of Inherited Metabolic Disorders, National Institute of Neuroscience"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iio","family":"Masaaki","sequence":"additional","affiliation":[{"name":"National Center of Neurology and Psychiatry, and the Department of Radiology, National Nakano Chest Hospital, Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1991,7,1]]},"reference":[{"key":"atypb1","first-page":"723","volume":"116","author":"Rett A.","year":"1966","journal-title":"Wien Med Wochenschr"},{"key":"atypb2","unstructured":"Rett A.: Cerebral atrophy associated with hyperammonemia, in Vinken PJ, Bruuyn GW (eds): Handbook of Clinical Neurology, vol 29. 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