{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:14:54Z","timestamp":1777803294999,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1993,10,1]],"date-time":"1993-10-01T00:00:00Z","timestamp":749433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:p>In order to explore possible pathophysiologic involvement of the brain stem in infantile spasms, we retrospectively compared clinical and electroencephalographic (EEG) features of 14 children with infantile spasms who had gross posterior fossa abnormalities on neuroimaging studies with 84 children with infantile spasms who had either normal neuroimaging (n = 19) or supratentorial abnormalities (n = 65). Children with posterior fossa abnormalities had lower mean initial and follow-up developmental quotients compared to those with normal imaging or supratentorial abnormalities alone. Age of onset of infantile spasms, latency to treatment, response to steroids, and follow-up EEG pattern were not significantly different among the three groups. Six children (6%) had Dandy-Walker cysts, an association rarely reported with infantile spasms. We conclude that the presence of posterior fossa abnormalities in patients with infantile spasms portends a relatively poor developmental outcome. (J Child Neurol 1993;8:360-365).<\/jats:p>","DOI":"10.1177\/088307389300800413","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T02:13:25Z","timestamp":1230084805000},"page":"360-365","source":"Crossref","is-referenced-by-count":8,"title":["Posterior Fossa Abnormalities in Children With Infantile Spasms"],"prefix":"10.1177","volume":"8","author":[{"given":"Raphael","family":"Schiffmann","sequence":"first","affiliation":[{"name":"Pediatric Neurology Unit, Hadassah University Hospital, Jerusalem, Israel, Division of Pediatric Neurology, New England Medical Center Hospitals, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn B.","family":"Mannheim","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, New England Medical Center Hospitals, Boston, MA, Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl E.","family":"Stafstrom","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, New England Medical Center Hospitals, Boston, MA, Department of Neurology, Children's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan D.","family":"Hamburger","sequence":"additional","affiliation":[{"name":"Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory L.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children's Hospital, Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36651-2"},{"key":"atypb2","unstructured":"Hrachovy RA, Frost JD Jr: Infantile spasms: A disorder of the developing nervous system, in Kellaway P, Noebels JL (eds): Problems and Concepts in Developmental Neurophysiology. 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