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The progressive nature of the encephalopathy in our cases was documented by serial clinical examination, electroencephalograms, magnetic resonance imaging, and positron emission tomographic scans. The natural history of gliomatosis cerebri was determined by a retrospective review of the literature of 160 cases in 85 reports. The most common neurologic symptoms and signs included corticospinal tract deficits (58%), dementia\/mental retardation (44%), headache (39%), seizures (38%), cranioneuropathies (37%), increased intracranial pressure (34%), and spinocerebellar deficits (33%). The most commonly involved central nervous system structures were the centrum semiovale and cerebrum (76%), mesencephalon (52%), pons (52%), thalamus (43%), basal ganglia (34%), and the cerebellum (29%). Fifty-two percent of patients were dead within 12 months of onset. Different grades of glial neoplasm may also coexist within gliomatosis cerebri such as astrocytoma with anaplastic astrocytoma, atypical or anaplastic oligodendroglioma, and glioblastoma multiforme. Hypotheses regarding the pathogenesis of gliomatosis cerebri include blastomatous dysgenesis, diffuse infiltration, multicentric origin, in situ proliferation, and \"field transformation.\" The biologic determinants of whether a transformed glial cell behaves as a relatively localized tumor mass or truly loses anchorage dependence to become migratory as well as proliferative are not understood. (J Child Neurol 1995;10:37-45).<\/jats:p>","DOI":"10.1177\/088307389501000111","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T02:13:25Z","timestamp":1230084805000},"page":"37-45","source":"Crossref","is-referenced-by-count":94,"title":["Gliomatosis Cerebri Presenting as Intractable Epilepsy During Early Childhood"],"prefix":"10.1177","volume":"10","author":[{"given":"Mark T.","family":"Jennings","sequence":"first","affiliation":[{"name":"Department of Neurology, Vanderbilt School of Medicine, Nashville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghana","family":"Frenchman","sequence":"additional","affiliation":[{"name":"University of Tennessee Medical School Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Shehab","sequence":"additional","affiliation":[{"name":"Wayne State Medical School Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahlon 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