{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T09:49:02Z","timestamp":1777801742840,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:p>A patient with homocystinuria due to cystathionine \u03b2-synthase deficiency developed severe progressive polymyoclonus and ataxia. To our knowledge, this is the first time polymyoclonus and ataxia have been reported in association with homocystinuria. Although cerebrovascular thrombosis is usually thought to be responsible for neurologic dysfunction in homocystinuric patients, no infarctions were demonstrated on magnetic resonance imaging scans in our case. We have previously reported that baclofen dramatically improved the polymyoclonus and ataxia in a patient with Unverricht-Lundborg disease. Baclofen given to our patient reversed the polymyoclonus and the ataxia as well. This suggests that patients with polymyoclonus and ataxia, no matter what the etiology, may benefit from the use of baclofen. (J Child Neurol 1995; 10:294-296).<\/jats:p>","DOI":"10.1177\/088307389501000408","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T02:13:25Z","timestamp":1230084805000},"page":"294-296","source":"Crossref","is-referenced-by-count":8,"title":["Baclofen in the Treatment of Polymyoclonus and Ataxia in a Patient With Homocystinuria"],"prefix":"10.1177","volume":"10","author":[{"given":"Yasser","family":"Awaad","sequence":"first","affiliation":[{"name":"Department of Neurology, New York University Medical Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Sansaricq","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University Medical Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Moroney","sequence":"additional","affiliation":[{"name":"Department of Neurology, New York University Medical Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irving","family":"Fish","sequence":"additional","affiliation":[{"name":"Department of Neurology, New York University Medical Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastassios","family":"Kyriakakos","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University Medical Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma E.","family":"Snyderman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University Medical Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.38.201.425"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)91290-1"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.16.4.407"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1965.00470050003001"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.17.4.427"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(65)80121-4"},{"key":"atypb7","first-page":"357","volume":"79","author":"Chou SM","year":"1965","journal-title":"Arch Pathol"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870060213"},{"issue":"4","key":"atypb9","first-page":"S90","volume":"20","author":"Awaad Y.","year":"1993","journal-title":"Can J Neurol Sci"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)90842-7"},{"key":"atypb11","unstructured":"Olney JWL: Toxic effects of glutamate and related amino acids on the developing central nervous system, in Nyhan WL (ed): Hereditable Disorders of Amino Acids Metabolism. 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