{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:10:44Z","timestamp":1784005844474,"version":"3.55.0"},"reference-count":63,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:p>Congenital adrenal hyperplasia results from an adrenal enzyme deficiency, that causes an underproduction of glucocorticoids and sometimes mineralocorticoids and a resultant overproduction of androgens, until treatment with replacement glucocorticoids is instituted. The goal of this study was to determine the frequency and etiology of white-matter changes and temporal lobe atrophy demonstrable on magnetic resonance imaging (MRI) in a group of children and young adults with congenital adrenal hyperplasia. About one third of the patients evidenced white-matter abnormalities or temporal lobe atrophy. All patients, except one with a known stroke, had normal neurologic examinations. Exposure to excess exogenous glucocorticoids in the process of being treated for congenital adrenal hyperplasia is the most theoretically appealing explanation for these MRI findings. However, the relationship of MRI findings to treatment status (over- versus under-suppressed) does not run in clear parallel. (J Child Neurol 1997;12:181-186).<\/jats:p>","DOI":"10.1177\/088307389701200306","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T02:13:25Z","timestamp":1230084805000},"page":"181-186","source":"Crossref","is-referenced-by-count":53,"title":["Magnetic Resonance Imaging in the Congenital Adrenal Hyperplasia Population: Increased Frequency of White-Matter Abnormalities and Temporal Lobe Atrophy"],"prefix":"10.1177","volume":"12","author":[{"given":"Ruth","family":"Nass","sequence":"first","affiliation":[{"name":"Department of Neurology, New York University Medical Center, Department of Pediatrics, New York Hospital-Comell Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Heier","sequence":"additional","affiliation":[{"name":"Department of Radiology, New York Hospital-Comell Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Moshang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Oberfield","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajax","family":"George","sequence":"additional","affiliation":[{"name":"Department of Radiology, New York University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"New","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York Hospital-Comell Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis W.","family":"Speiser","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, North Shore University Hospital, Department of Pediatrics, New York Hospital-Comell Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1997,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530360046016"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530320052012"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1001\/archneur.1992.00530320049011","volume":"49","author":"Schmidt R.","year":"1992","journal-title":"Arch Neurol"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530300062011"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530290141024"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.6.1084"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530040034016"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.11.1470"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530020061017"},{"key":"atypb10","first-page":"509","volume":"162","author":"Kirkpatrick JB","year":"1987","journal-title":"Neuroradiology"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.10.1285"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.147.2.187"},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0140-6736(88)92855-3","author":"de Leon M.","year":"1988","journal-title":"Lancet"},{"key":"atypb14","first-page":"675","volume":"6","author":"Brant-Zawadski M.","year":"1985","journal-title":"Am J Neuroradiol"},{"key":"atypb15","first-page":"567","volume":"7","author":"George AE","year":"1986","journal-title":"Am J Neuroradiol"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198702000-00004"},{"key":"atypb17","first-page":"425","volume":"9","author":"Soges L.","year":"1988","journal-title":"Am J Neuroradiol"},{"key":"atypb18","first-page":"703","volume":"10","author":"Hendric H.","year":"1989","journal-title":"Am J Neuroradiol"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.7.998"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1159\/000116401"},{"key":"atypb21","first-page":"359","volume":"151","author":"Nowell M.","year":"1988","journal-title":"Am J Radiol"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(94)90059-0"},{"key":"atypb23","unstructured":"Speiser P., New M.: An update of congenital adrenal hyperplasia, in Lifshitz F (ed): Pediatric Endocrinology. New York, Dekker, 1990 , pp 307-332."},{"key":"atypb24","volume-title":"Textbook of Endocrinology","author":"Williams RH","year":"1981"},{"key":"atypb25","unstructured":"Dallman M.: Corticosterone replacement in adrenalectomized rats: Insights into the regulation of ACTH secretion, in Rose F (ed): The Control of the Hypothalamic-Pituitary-Adrenocortical Axis . Madison, CT: International Universities Press, 1990, pp 399-426."},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80128-3"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-69-1-191"},{"issue":"3","key":"atypb28","first-page":"91","volume":"12","author":"New MI","year":"1989","journal-title":"J Endocrinol Invest"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81064-9"},{"key":"atypb30","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1210\/jcem-30-3-361","volume":"30","author":"New M.","year":"1970","journal-title":"J Clin Endocrinol"},{"key":"atypb31","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/ajpcell.1985.249.5.C527","volume":"249","author":"Akana S.","year":"1985","journal-title":"Am J Physiol"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198701223160402"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195712122572402"},{"key":"atypb34","first-page":"929","volume":"10","author":"Heier LA","year":"1989","journal-title":"Am J Neuroradiol"},{"key":"atypb35","first-page":"101","volume":"11","author":"George AE","year":"1990","journal-title":"Am J NeuroradioL"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1159\/000184635"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530310095018"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540050044013"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.2.761"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.151.3.551"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.9.1683"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.5.883"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1983.04050030032005"},{"key":"atypb44","volume-title":"Stroke","author":"Barnett H","year":"1986"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711053171905"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1986.tb12939.x"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90286-0"},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90528-4"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(92)90204-D"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(86)90167-6"},{"key":"atypb51","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(88)90251-8"},{"key":"atypb52","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1523\/JNEUROSCI.05-05-01222.1985","volume":"5","author":"Sapolsky R.","year":"1985","journal-title":"J Neurosci"},{"key":"atypb53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1972.tb05124.x"},{"key":"atypb54","doi-asserted-by":"publisher","DOI":"10.1126\/science.4035356"},{"key":"atypb55","unstructured":"Raley-Susman K., Sapolsky R.: Glucocorticoid effects on neuronal development and vitality, in Lou H, Greisen G, Falck Larsen J (eds): Brain Lesions in the Newborn. Munksgaard, Copenhagen, 1994, pp 257-268."},{"key":"atypb56","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(85)90126-9"},{"key":"atypb57","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-197801000-00003"},{"key":"atypb58","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198002000-00004"},{"key":"atypb59","doi-asserted-by":"crossref","unstructured":"McEwen B. : Glucocorticoids and the hippocampus, in Garten D (ed): Current Topics in Neuroendocrinology. New York, Springer-Verlag, 1982, pp 1-22.","DOI":"10.1007\/978-3-642-68336-7_1"},{"key":"atypb60","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90778-A"},{"key":"atypb61","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(92)90079-F"},{"key":"atypb62","first-page":"57","volume":"7","author":"Oberfield S.","year":"1994","journal-title":"J Acquir Immune Defic Syndr"},{"key":"atypb63","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(91)90078-8"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088307389701200306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/088307389701200306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:32:16Z","timestamp":1777494736000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/088307389701200306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["10.1177\/088307389701200306"],"URL":"https:\/\/doi.org\/10.1177\/088307389701200306","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}