{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:05:40Z","timestamp":1784354740769,"version":"3.55.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1997,6,1]],"date-time":"1997-06-01T00:00:00Z","timestamp":865123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[1997,6]]},"abstract":"<jats:p>In this study we sought to investigate parasympathetic activity among children with severe cyanotic breath-holding spells by examining respiratory sinus arrhythmia. The study sample was composed of two groups of patients, 16 subjects with cyanotic breath-holding spells (5 male, 11 female; mean age, 37.5 mo) and 17 controls (8 male, 9 female; mean age, 37.7 mo). Each subject's electrocardiogram was recorded in a quiet room and digitized by an 80386 personal computer during five 1-minute periods. R\u2014R intervals within each 1-minute period were converted to heart rate in 120 successive 0.5-second intervals. The resultant heartrate time series was converted to its underlying frequency composition by a fast Fourier transform and averaged across minutes. Respiratory sinus arrhythmia was defined as the variability in the time series over a frequency range (0.096-0.48 Hz) corresponding to a range of respiratory rates from 6 to 30 breaths per minute. Analysis revealed after ANCOVA adjustment for age and gender with subject group and frequency bin as dependent measures, that subjects with cyanotic breath-holding spells had similar variability in their heart rates as did controls (group \u00d7 frequency bin: F = 0.74, P = 0.71). This study supports the hypothesis that autonomic dysregulation in cyanotic breath-holding spells is not due to a primary disturbance in central parasympathetic control over cardiac rate and rhythm. ( J Child Neurol 1997;12:260-262).<\/jats:p>","DOI":"10.1177\/088307389701200408","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T02:13:25Z","timestamp":1230084805000},"page":"260-262","source":"Crossref","is-referenced-by-count":16,"title":["Respiratory Sinus Arrhythmia in Children With Severe Cyanotic Breath-Holding Spells"],"prefix":"10.1177","volume":"12","author":[{"suffix":"Jr","given":"Francis J.","family":"DiMario","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology, University of Connecticut, Farmington, Connecticut Children's Medical Center Hartford, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry at The University of Connecticut, Farmington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Volpe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry at The University of Connecticut, Farmington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Baxter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry at The University of Connecticut, Farmington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1997,6,1]]},"reference":[{"key":"atypb1","first-page":"125","volume":"146","author":"DiMario FJ","year":"1992","journal-title":"Am J Dis Child"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1542\/peds.39.4.563","volume":"39","author":"Lombroso CT","year":"1967","journal-title":"Pediatrics"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.53.3.193"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/000992289002900102"},{"key":"atypb5","first-page":"465","volume":"30","author":"DiMario FJ","year":"1991","journal-title":"Ann Neurol"},{"key":"atypb6","doi-asserted-by":"crossref","unstructured":"Porges SW: Respiratory sinus arrhythmia: Physiological basis, quantitative methods, clinical implications, in Grossman P, Janssen KH, Vaitl D, (eds): Cardio-Respiratory and Cardio-Somatic Psychophysiology. 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