{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:12:47Z","timestamp":1791112367285,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:p>We studied the topographic relationships between cortical and subcortical lesions shown on magnetic resonance images (MRI) and sources of epileptiform activity in a series of nine children with intractable epilepsy and tuberous sclerosis complex. Although video-electroencephalographic (EEG) monitoring was suggestive of a frontal seizure onset, interictal EEG was, in seven of nine cases, in the form of apparently bisynchronous discharges. In all cases, the use of a short time lag estimation procedure based on a nonlinear correlation function between surface recorded EEG signals allowed the detection of a lateralized onset of EEG paroxysmal activity. Furthermore, a computerized method based on a source localization EEG-MRI image fusioning procedure, has revealed a topographic concordance between well-defmed frontal cortical lesions shown on MRI and site of onset of paroxysmal discharges. Lennox-like EEG patterns frequently reported in children with tuberous sclerosis complex could be the result of the tendency of frontal tubers to induce secondary bilateral synchrony, with implications in the medical and eventually surgical management of the often drug-resistant associated seizures. (J Child Neurol 1998;13:33-38).<\/jats:p>","DOI":"10.1177\/088307389801300106","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T02:13:25Z","timestamp":1230084805000},"page":"33-38","source":"Crossref","is-referenced-by-count":33,"title":["Frontal Lobe Epilepsy Associated With Tuberous Sclerosis: Electroencephalographic-Magnetic Resonance Image Fusioning"],"prefix":"10.1177","volume":"13","author":[{"given":"Stefano","family":"Seri","sequence":"first","affiliation":[{"name":"Department of Child Neurology and Psychiatry, University \"La Sapienza,\" Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Cerquiglini","sequence":"additional","affiliation":[{"name":"Department of Child Neurology and Psychiatry, University \"La Sapienza,\" Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pisani","sequence":"additional","affiliation":[{"name":"Department of Child Neurology and Psychiatry, University \"La Sapienza,\" Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph M.","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hopital Cantonale Universitaire, G\u00e9n\u00e8ve"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto D.","family":"Pascual Marqui","sequence":"additional","affiliation":[{"name":"\"Key Institute for Mind-Brain Research,\" Department of Psychiatry, University of Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Curatolo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, University \"Tor Vergata,\" Rome, and IRCCS \"S. 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