{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:19:59Z","timestamp":1791087599867,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[1999,12]]},"abstract":"<jats:p>Children with epilepsy, as a group, have a greater risk for developing learning problems as comorbid disorders. It is unknown which factors contribute to the development of such learning problems; therefore, our current knowledge does not allow the prediction of educational delay in an individual child with epilepsy. This study aimed at excluding as many factors as possible that could interfere with the analysis of the impact of epilepsy on learning. From patients referred to us in 1997 (N = 123), children were included with mild global learning impairment, defined as educational delay between 6 months and 1 year and no other apparent reason for learning impairment except for epilepsy (ie, excluding children with dyslexia, attention-deficit hyperactivity disorder, or mental handicap). A total of 44 patients fulfilled this criterion: 31 also had epilepsy (experimental group); the remaining 13 patients with similar mild learning impairment but without epilepsy were used as controls. In the experimental group two subgroups were distinguished on the basis of onset of learning impairment: in group A ( n = 17) the learning problems are not unexpected as they were preceded by mild developmental delay; in group B ( n = 14) the problems are unexpected and had a sudden onset. The two experimental groups differed from the control group on a number of variables, such as gender and the incidence of perinatal complications. More differences have been found between the two experimental groups: group B is selected from a larger group: all children with mild global learning impairment with sudden onset. In this group considerably more children with epilepsy have been found compared to the children with developmental delay; moreover the epilepsy is more often characterized in these children as \"unexpected,\" that is, there was no previous established diagnosis of epilepsy, the symptoms were mostly unclear and behavioral in make-up (attentional lapses, etc); the electroencephalogram plays a much greater role in the diagnosis in this group, especially in demonstrating seizures; finally, the children in this group more frequently have neuropsychologic impairment. Children with epilepsy can have mild global learning difficulties, especially in the period after the onset of seizures. This group can be divided in a group with \"trait-dependent learning difficulties,\" that is learning difficulties based on developmental delay, and a group with \"state-dependent learning difficulties.\" The focus in our study was on this latter group, consisting of children with sudden and unexpected decline of results in school. The crucial finding in this group is the relatively frequent demonstration of difficult-to-detect seizures, demonstrating that an uncontrolled epilepsy can cause a decline in school results even when the seizures are of short duration and have subtle symptoms. (J Child Neurol 1999;14:795-800).<\/jats:p>","DOI":"10.1177\/088307389901401205","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T19:24:33Z","timestamp":1201202673000},"page":"795-800","source":"Crossref","is-referenced-by-count":42,"title":["An Open, Nonrandomized Clinical Comparative Study Evaluating the Effect of Epilepsy on Learning"],"prefix":"10.1177","volume":"14","author":[{"given":"Albert P.","family":"Aldenkamp","sequence":"first","affiliation":[{"name":"Department of Behavioral Science and Psychological Services, Epilepsy Center Kempenhaeghe, Heeze, , Faculty of Social and Behavioral Science, University of Amsterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouterina C.G.","family":"Overweg-Plandsoen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Academic Medical Center The Netherlands, Department of Neurology and the Program for Epilepsy and Learning Disabilities, Epilepsy Center Kempenhaeghe, Heeze"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Arends","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Epilepsy Center Kempenhaeghe, Heeze"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1999,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1978.tb15256.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1986.tb03606.x"},{"key":"atypb3","unstructured":"Thompson PJ: Educational attainment in children and young people with epilepsy , in Oxley J, Stores G (eds): Epilepsy and Education. 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New York, CRC Press, 1995, pp 225-239."},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1990.tb05874.x"},{"key":"atypb7","volume-title":"A Neuropsychiatric Study in Childhood; Clinics in Developmental Medicine","author":"Rutter M.","year":"1970"},{"key":"atypb8","first-page":"418","volume":"32","author":"Green JB","year":"1971","journal-title":"Dis Nerve Syst"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1974.tb03395.x"},{"key":"atypb10","unstructured":"Ross EM, Tookey P.: Educational needs and epilepsy in childhood, in Trimble MR, Reynolds EH (eds): Epilepsy, Behaviour and Cognitive Function. Chichester , John Wiley & Sons, 1988, pp 87-97."},{"key":"atypb11","volume-title":"Neuropsychology of Learning Disabilities\u2014Essentials of Subtype Analysis","author":"Rourke BP","year":"1985"},{"key":"atypb12","unstructured":"Strang J., Rourke BP: Adaptive behavior of children who exhibit specific arithmetic disabilities and associated neuropsychological abilities and deficits, in Rourke BP (ed): Neuropsychology of Learning Disabilities\u2014Essentials of Subtype Analysis. New York, Guilford, 1985, pp 302-331."},{"key":"atypb13","unstructured":"Strang J.: Educational and related treatment considerations concerning the child with epilepsy: A developmental neuropsychological approach, in Aldenkamp AP, Alpherts WCJ , Meinardi H, Stores G (eds): Education and Epilepsy. Berwyn, IL, Swets & Zeitlinger, 1987, pp 118-135."},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S1059-1311(05)80157-8"},{"key":"atypb15","volume-title":"Kema-van Leggelo MKG: Handleiding G.S.O. 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