{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:39:52Z","timestamp":1761007192229,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Chronic renal failure patients have been known to develop vitamin A toxicity, but a descriptive study of hypervitaminosis A in patients with acute renal failure (ARF) has not yet been published. The authors observed hypervitaminosis A in pediatric hematopoietic stem cell transplant (HSCT) patients. <jats:italic>Methods:<\/jats:italic> All HSCT patients admitted between January 2001 and May 2006 who experienced ARF, received renal replacement therapy (RRT), and had a vitamin A level drawn were included in this retrospective, descriptive study. Molar ratios of vitamin A and retinol\u2010binding protein (RBP) were calculated to more accurately assess vitamin A status. Nineteen patients met the criteria for this study. <jats:italic>Results:<\/jats:italic> At initial testing (generally between days 6 and 10 after initiation of RRT), 17 of the 19 patients had abnormally elevated vitamin A levels for their age. Molar ratios of vitamin A to RBP were elevated in 6 patients at initial testing. Prescribed vitamin A intake information (parenteral and enteral) was available for most patients; all but 3 had an average daily intake greater than 2000 IU\/kg over the 30 days prior to RRT initiation. Many patients had symptoms possibly related to vitamin A toxicity, although interpretation of hair, skin, and liver abnormalities are difficult to ascertain in HSCT patients. Seven patients had other findings that may have been associated with vitamin A toxicity. <jats:italic>Conclusion:<\/jats:italic> Children undergoing HSCT who receive nutrition support (predominantly parenteral nutrition), experience ARF, and require RRT are at risk for hypervitaminosis A and toxicity.<\/jats:p>","DOI":"10.1177\/0884533608327082","type":"journal-article","created":{"date-parts":[[2008,11,24]],"date-time":"2008-11-24T21:02:17Z","timestamp":1227560537000},"page":"621-629","source":"Crossref","is-referenced-by-count":14,"title":["Hypervitaminosis A in Pediatric Hematopoietic Stem Cell Patients Requiring Renal Replacement Therapy"],"prefix":"10.1002","volume":"23","author":[{"given":"Ann Connell","family":"Lipkin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polly","family":"Lenssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/15.7.272"},{"key":"e_1_2_9_3_1","first-page":"40","article-title":"Hypervitaminosis A toxicity in regular hemodialysis patients","volume":"30","author":"Ono K.","year":"1984","journal-title":"Trans Am Soc Artif Intern Organs"},{"issue":"6","key":"e_1_2_9_4_1","first-page":"S1","article-title":"Clinical practice guidelines for nutrition in chronic renal failure. 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