{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:01:50Z","timestamp":1773921710570,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T00:00:00Z","timestamp":1271894400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Parenteral nutrition\u2013associated liver disease (PNALD) is a potentially fatal complication for children with intestinal failure. Fish oil\u2013based lipid emulsions have shown promise for the treatment of PNALD but are not readily available. Six cases are presented in which cholestasis resolved after soybean lipid emulsion (SLE) was removed from parenteral nutrition (PN) and enteral fish oil was given.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review at a tertiary children's hospital (July 2003 to August 2008) identified 6 infants with intestinal failure requiring PN for &gt;6 months who developed severe hepatic dysfunction that was managed by eliminating SLE and providing enteral fish oil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three infants with short bowel syndrome requiring prolonged PN developed cholestasis. SLE was removed in 6 of these patients, and 4 of the 6 received enteral fish oil. Standard PN included 2\u20103 g\/kg\/d SLE with total PN calories ranging from 57 to 81 kcal\/kg\/d at the time of SLE removal. Hyperbilirubinemia resolved after elimination of SLE within 1.8\u20105.4 months. Total PN calories required to maintain growth generally did not change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Temporary elimination of SLE and supplementation with enteral fish oil improved cholestasis in PN\u2010dependent infants. Further trials are needed to evaluate this management strategy.<\/jats:p><\/jats:sec>","DOI":"10.1177\/0884533610361477","type":"journal-article","created":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T13:00:27Z","timestamp":1271941227000},"page":"199-204","source":"Crossref","is-referenced-by-count":56,"title":["Elimination of Soybean Lipid Emulsion in Parenteral Nutrition and Supplementation With Enteral Fish Oil Improve Cholestasis in Infants With Short Bowel Syndrome"],"prefix":"10.1002","volume":"25","author":[{"given":"Michael D.","family":"Rollins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric R.","family":"Scaife","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Daniel","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecka L.","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia W.","family":"Mulroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda S.","family":"Book","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,22]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.10.066"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-007-0040-1"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-7-200004040-00003"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(97)00233-5"},{"key":"e_1_2_3_6_1","first-page":"1467","article-title":"Liver disease associated with long\u2010term parenteral nutrition in children","volume":"26","author":"Colomb V","year":"1994","journal-title":"Transplant Proc"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-008-2174-0"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.11.004"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607100024006345"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2248"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1998.tb01122.x"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.05.020"},{"key":"e_1_2_3_13_1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1542\/peds.68.5.738","article-title":"Use of intravenous fat emulsions in pediatric patients","volume":"68","author":"American Academy of Pediatrics, Committee on Nutrition","year":"1981","journal-title":"Pediatrics"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000206309.83570.45"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.01.005"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2662"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.855"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.01.009"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31819773cf"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0884533610361477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0884533610361477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0884533610361477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:48:25Z","timestamp":1760960905000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0884533610361477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1177\/0884533610361477"],"URL":"https:\/\/doi.org\/10.1177\/0884533610361477","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"value":"0884-5336","type":"print"},{"value":"1941-2452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}