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It is involved in DNA synthesis, RNA transcription, and cell division and activation. It is a critical component in many zinc protein\/enzymes, including critical zinc transcription factors. Zinc deficiency\/altered metabolism is observed in many types of liver disease, including alcoholic liver disease (ALD) and viral liver disease. Some of the mechanisms for zinc deficiency\/altered metabolism include decreased dietary intake, increased urinary excretion, activation of certain zinc transporters, and induction of hepatic metallothionein. Zinc deficiency may manifest itself in many ways in liver disease, including skin lesions, poor wound healing\/liver regeneration, altered mental status, or altered immune function. 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