{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:33:29Z","timestamp":1791920009102,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: The efficacy of some probiotic strains for the management of lactose intolerance remains to be established. <jats:italic>Aim<\/jats:italic> :To evaluate the effects of a 4\u2010week consumption of a probiotic product containing <jats:italic>Lactobacillus casei<\/jats:italic> Shirota and <jats:italic>Bifidobacterium breve<\/jats:italic> Yakult (10<jats:sup>7<\/jats:sup>\u201310<jats:sup>9<\/jats:sup> CFU of each strain) on symptoms and breath hydrogen exhalation after a lactose load in lactose\u2010intolerant patients and whether the beneficial results persisted after probiotic discontinuation. <jats:italic>Methods<\/jats:italic>: Twenty\u2010seven patients with lactose maldigestion and intolerance participated in this study, which comprised 4 hydrogen breath tests: baseline condition (20 g lactose), after lactase ingestion (9000 FCC units), at the end of 4\u2010week probiotic supplementation, and a follow\u2010up test performed 3 months after probiotic discontinuation. For each test, the area under the breath hydrogen concentration vs time curve (AUC<jats:sub>180 min<\/jats:sub>) was calculated, and symptom scores were recorded. <jats:italic>Results<\/jats:italic>: The probiotic combination significantly reduced symptom scores (<jats:italic>P<\/jats:italic> &lt; .01) and breath hydrogen AUC (<jats:italic>P<\/jats:italic> = .04) compared with the baseline condition. The comparison with the lactase test showed that symptom scores were similar (<jats:italic>P<\/jats:italic> &gt; .05), despite the significantly higher (<jats:italic>P<\/jats:italic> = .01) AUC values after probiotic use. In the follow\u2010up test, symptom scores and breath hydrogen AUC values remained similar to those found at the end of probiotic intervention. <jats:italic>Conclusion<\/jats:italic>: Four\u2010week consumption of a probiotic combination of <jats:italic>L casei<\/jats:italic> Shirota and <jats:italic>B breve<\/jats:italic> Yakult seems to improve symptoms and decrease hydrogen production intake in lactose\u2010intolerant patients. These effects may persist for at least 3 months after suspension of probiotic consumption.<\/jats:p>","DOI":"10.1177\/0884533612440289","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T20:18:11Z","timestamp":1331237891000},"page":"247-251","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":92,"title":["Beneficial Effects of Long\u2010Term Consumption of a Probiotic Combination of <i>Lactobacillus casei<\/i> Shirota and <i>Bifidobacterium breve<\/i> Yakult May Persist After Suspension of Therapy in Lactose\u2010Intolerant Patients"],"prefix":"10.1002","volume":"27","author":[{"given":"Camila Casuccio","family":"Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f4nia Let\u00edcia Silva","family":"Lorena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia Regina","family":"Pavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Midori Imamura","family":"Akasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Aparecida","family":"Mesquita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,8]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03557.x"},{"key":"e_1_2_4_3_1","first-page":"1845","article-title":"Lactose intolerance","volume":"65","author":"Swagerty DL","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb00867.x"},{"key":"e_1_2_4_5_1","first-page":"133","article-title":"Primary lactose malabsorption in healthy Brazilian adult caucasoid, negroid and mongoloid 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