{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T13:22:27Z","timestamp":1775395347002,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T00:00:00Z","timestamp":1344211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T00:00:00Z","timestamp":1344211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Hyperhomocysteinemia might be at least partially due to compromised B vitamin status in critically ill patients and has been linked with critical illness. This study was conducted to examine the association between plasma homocysteine with B vitamins and clinical outcomes in critically ill surgical patients. <jats:italic>Methods<\/jats:italic>: Thirty\u2010two patients in the surgical intensive care unit (SICU) were enrolled. Disease severity (Acute Physiology and Chronic Health Evaluation II score), hematological values, serum and erythrocyte folate, serum vitamin B<jats:sub>12<\/jats:sub>, plasma, and erythrocyte pyridoxal 5\u2032\u2010phosphate (PLP) were determined within 24 hours of admission and again after 7 days. <jats:italic>Results<\/jats:italic>: The prevalence of hyperhomocysteinemia in the patients was either 46.9% (plasma homocysteine \u226512 \u00b5mol\/L) or 31.3% (plasma homocysteine \u226515 \u00b5mol\/L) on day 1 in the SICU and increased to 62.5% (plasma homocysteine \u226512 \u00b5mol\/L) and 37.5% (plasma homocysteine \u226515 \u00b5mol\/L) on day 7 after admission to the SICU. Plasma homocysteine, serum folate, and vitamin B<jats:sub>12<\/jats:sub> significantly increased by day 7, whereas plasma and erythrocyte PLP remained constant throughout the study. Plasma homocysteine was not correlated with serum folate and vitamin B<jats:sub>12<\/jats:sub>. However, plasma and erythrocyte PLP on day 1 were adversely associated with day 1 levels of plasma homocysteine after adjusting for potential confounders. Plasma homocysteine on day 1 or changes (\u0394 day 7 \u2013 day 1) did not show any association with clinical outcomes. <jats:italic>Conclusions<\/jats:italic>: Lower plasma PLP might be a significant factor for increased plasma homocysteine in critically ill surgical patients. The association between plasma homocysteine and clinical outcomes was not found.<\/jats:p>","DOI":"10.1177\/0884533612449654","type":"journal-article","created":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T22:05:35Z","timestamp":1344290735000},"page":"695-700","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Higher Plasma Homocysteine Is Associated With Lower Vitamin B<sub>6<\/sub> Status in Critically Ill Surgical 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