{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:02:34Z","timestamp":1778007754288,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T00:00:00Z","timestamp":1344470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T00:00:00Z","timestamp":1344470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> This study aimed to compare the effect of 2 lipid emulsions (LEs), a medium\u2010chain triglyceride (MCT)\/\u03c9\u20103\u2013polyunsaturated fatty acid (PUFA)\u2013containing LE and a soybean\u2010based LE, on the incidence of neonatal cholestasis, bronchopulmonary dysplasia (BPD), and lipid profile of preterm infants. <jats:italic>Patients and Methods:<\/jats:italic> In this prospective, observational study, 2 groups of preterm neonates, the very low birth weight (VLBW) (n = 129) and the low birth weight (LBW) groups (n = 153), which received parenteral LEs for at least 7 days, were included. Infants received either MCT\/\u03c9\u20103\u2013PUFA\u2013containing LE (SMOFlipid, subgroup I) or soybean\u2010based LE (Intralipid, subgroup II) according to the attending neonatologist's preference and availability. Full biochemical assessment was performed on days of life 15, 30, and 45 and on discharge. <jats:italic>Results:<\/jats:italic> Of the VLBW infants, 7.4% and 13.3% of infants in subgroups I and II, respectively, developed cholestasis (<jats:italic>P<\/jats:italic> = .39; odds ratio [OR], 0.52; 95% confidence interval [CI], 0.15\u20131.76). The duration of LE administration was independently associated with cholestasis (<jats:italic>P<\/jats:italic> &lt; .001; OR, 0.925; 95% CI, 0.888\u20130.963). The maximum amounts of lipids administered ranged between 1.6 and 3.6 g\/kg\/d in both VLBW subgroups. The VLBW subgroup I had lower incidence of BPD, lower alkaline phosphatase and phosphate, higher high\u2010density lipoprotein (HDL), and lower cholesterol\u2010to\u2010HDL ratio on discharge than the VLBW subgroup II. The type of LE was independently associated with BPD and alkaline phosphatase. In the LBW group, the type of LE was not associated with clinical and biochemical parameters. <jats:italic>Conclusion:<\/jats:italic> In VLBW infants, the MCT\/\u03c9\u20103\u2013PUFA\u2013containing LE administration is associated with decreased BPD and more favorable lipoprotein profile. Although a trend toward a lower incidence of cholestasis was observed, a preventive effect of MCT\/\u03c9\u20103\u2013PUFA\u2013containing LE on parenteral nutrition\u2013associated cholestasis is not supported.<\/jats:p>","DOI":"10.1177\/0884533612454547","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T02:27:54Z","timestamp":1344565674000},"page":"817-824","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["Cholestasis, Bronchopulmonary Dysplasia, and Lipid Profile in Preterm Infants Receiving MCT\/\u03c9\u20103\u2013PUFA\u2013Containing or Soybean\u2010Based Lipid 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