{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:59:50Z","timestamp":1780639190648,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T00:00:00Z","timestamp":1345075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T00:00:00Z","timestamp":1345075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Loss of lean body develops from an imbalance in protein synthesis and catabolism and is associated with a variety of different disease and nondisease states, including severe malnutrition, cachexia, and physiologic age\u2010related loss (sarcopenia). Loss of lean body mass is prevalent among a significant proportion of the elderly population and has been associated with increased adverse clinical outcomes. Recognition of individuals at risk for low lean body mass may be difficult due to unequal distribution of losses across muscle and adipose compartments, and individuals who are both obese and sarcopenic demonstrate the highest risk for adverse events. Cross\u2010sectional imaging modalities provide an accessible and easily interpretable means of quantifying lean muscle content and are routine diagnostic tests for cancer patients. As a result, a growing body of literature has developed characterizing the importance of low lean body mass as a poor prognostic factor among cancer patients, regardless of age. Cancer patients, especially those with sarcopenic obesity, are at increased risk for treatment\u2010related toxicities from chemotherapy and increased overall mortality. Further investigations into the pathogenesis of muscle wasting among cancer patients are critical, as therapeutic oncologic interventions may inadvertently accelerate muscle catabolism. This review provides an overview of the definitions of low lean body mass, etiologic causes, clinical significance among cancer patients, and potential therapeutic interventions.<\/jats:p>","DOI":"10.1177\/0884533612457949","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:55:57Z","timestamp":1345164957000},"page":"593-598","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":64,"title":["Importance of Lean Body Mass in the Oncologic Patient"],"prefix":"10.1002","volume":"27","author":[{"given":"Susan","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,16]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/50.5.1231"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.2.473"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.2.378"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.2.465"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(98)00130-4"},{"issue":"6","key":"e_1_2_3_7_1","first-page":"408","article-title":"Linking age\u2010related changes in skeletal muscle mass and composition with metabolism and disease","volume":"9","author":"Janssen I","year":"2005","journal-title":"J Nutr Health Aging"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00246.2003"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2008"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2007.03.008"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06498.x"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009520"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50220.x"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.250"},{"key":"e_1_2_3_15_1","first-page":"11","article-title":"Human aging, muscle mass, and fiber type composition","volume":"50","author":"Lexell J","year":"1995","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00278.2006"},{"issue":"2","key":"e_1_2_3_17_1","first-page":"E210","article-title":"Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women","volume":"265","author":"Yarasheski KE","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.10.1206"},{"issue":"1","key":"e_1_2_3_19_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/ajcn\/66.1.192","article-title":"Standardization of nomenclature of body composition in weight loss","volume":"66","author":"Roubenoff R","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2008.03.008"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874609811003020090"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.6.2052S"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065874"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.035790"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18330"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50216.x"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.4.613"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.10.B359"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.17.1.527"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.5040\/9781492596950"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.73"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.570"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.2.271"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00744.2004"},{"key":"e_1_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70153-0"},{"key":"e_1_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.03.039"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029330"},{"key":"e_1_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199426040-00005"},{"key":"e_1_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000215)88:4<796::AID-CNCR10>3.0.CO;2-P"},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-3067"},{"key":"e_1_2_3_41_1","unstructured":"AsareE KnechtgesP GreenDet al.Low baseline lean body mass negatively predicts completion of neoadjuvant therapy in patients with resectable pancreatic cancer.Presented at: American Hepatopancreaticobiliary Association Annual Meeting; March 11 2012; Miami FL."},{"key":"e_1_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.9730"},{"issue":"3","key":"e_1_2_3_43_1","first-page":"CD002759","article-title":"Progressive resistance strength training for improving physical function in older adults","author":"Liu CJ","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/58.7.M618"},{"key":"e_1_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00362.2001"},{"key":"e_1_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0034-6"},{"key":"e_1_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI939"},{"issue":"3","key":"e_1_2_3_48_1","first-page":"E513","article-title":"Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first\u2010pass splanchnic extraction","volume":"277","author":"Volpi E","year":"1999","journal-title":"Am J Physiol"},{"issue":"4","key":"e_1_2_3_49_1","first-page":"E677","article-title":"High\u2010protein meals do not enhance myofibrillar synthesis after resistance exercise in 62\u2010 to 75\u2010yr\u2010old men and women","volume":"274","author":"Welle S","year":"1998","journal-title":"Am J Physiol"},{"key":"e_1_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00397.2002"}],"container-title":["Nutrition in Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0884533612457949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0884533612457949","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0884533612457949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:21:46Z","timestamp":1760966506000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0884533612457949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,16]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1177\/0884533612457949"],"URL":"https:\/\/doi.org\/10.1177\/0884533612457949","archive":["Portico"],"relation":{},"ISSN":["0884-5336","1941-2452"],"issn-type":[{"value":"0884-5336","type":"print"},{"value":"1941-2452","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,16]]}}}