{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T09:40:05Z","timestamp":1783244405547,"version":"3.54.6"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T00:00:00Z","timestamp":1373241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T00:00:00Z","timestamp":1373241600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: L\u2010carnosine (CAR) is an endogenous dipeptide. We aimed to determine the effects of CAR and its zinc complex polaprezinc (PLZ) on pressure ulcer healing in institutionalized long\u2010term care patients. <jats:italic>Methods<\/jats:italic>: This study was a nonrandomized controlled trial with a maximum 4\u2010week follow\u2010up. Forty\u2010two patients with stage II\u2013IV pressure ulcers for 4 or more weeks were allocated to 1 of 3 groups in order of recruitment: the control group (n = 14) was untreated, the PLZ group (n = 10) orally received 150 mg\/d PLZ (containing 116 mg CAR and 34 mg zinc), and the CAR group (n = 18) orally received 116 mg\/d CAR. Pressure ulcer severity was measured weekly using the Pressure Ulcer Scale for Healing (PUSH) score. <jats:italic>Results<\/jats:italic>: At baseline, no significant differences were found among groups in demographic and nutrition parameters and pressure ulcer characteristics (severity, size, and staging). After 4 weeks, the rate of pressure ulcer healing, assessed by the mean weekly improvement in PUSH score, was significantly greater in the CAR (1.6 \u00b1 0.2, <jats:italic>P<\/jats:italic> = .02) and PLZ groups (1.8 \u00b1 0.2, <jats:italic>P<\/jats:italic> = .009) than in the control group (0.8 \u00b1 0.2). The difference between the CAR and PLZ groups was not significant (<jats:italic>P<\/jats:italic> = .73). Actual dietary intakes over this period did not differ significantly among groups. <jats:italic>Conclusions<\/jats:italic>: Our results suggest that CAR and PLZ may almost equally accelerate pressure ulcer healing during 4 weeks. The results need confirmation by randomized controlled trials with larger sample sizes.<\/jats:p>","DOI":"10.1177\/0884533613493333","type":"journal-article","created":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T23:44:17Z","timestamp":1373327057000},"page":"609-616","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Effects of L\u2010Carnosine and Its Zinc Complex (Polaprezinc) on Pressure Ulcer Healing"],"prefix":"10.1002","volume":"28","author":[{"given":"Kensaku","family":"Sakae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Agata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Kamide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,8]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000350838.11854.0a"},{"key":"e_1_2_3_3_1","first-page":"176","article-title":"The Japanese Pressure Ulcer Surveillance Study: a retrospective cohort study to determine prevalence of pressure ulcers in Japanese hospitals","volume":"20","author":"Sanada H","year":"2008","journal-title":"WOUNDS"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00152192-200605000-00006"},{"key":"e_1_2_3_5_1","volume-title":"Prevention and Treatment of Pressure Ulcers: Clinical Practice Guideline","author":"National Pressure Ulcer Advisory Panel and European Pressure Ulcer Advisory Panel","year":"2009"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/11318340-000000000-00000"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4526(09)57003-9"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(97)00468-1"},{"key":"e_1_2_3_9_1","first-page":"843","article-title":"A role for carnosine in cellular maintenance","volume":"65","author":"Holliday R","year":"2000","journal-title":"Biochemistry (Mosc)"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.1836"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.06.004"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1993.73.1.79"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2006.00179.x"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665100000781"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00152192-200311000-00004"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.07.024"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.38.3140"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.100.165"},{"key":"e_1_2_3_19_1","first-page":"817","article-title":"Applicability of zinc complex of L\u2010carnosine for medical use","volume":"65","author":"Matsukura T","year":"2000","journal-title":"Biochemistry (Mosc)"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2011.2038"},{"key":"e_1_2_3_21_1","unstructured":"DiSilvestroRA.Discussion of the scientific and clinical documentation providing a basis for the safety of zinc carnosine.2002.http:\/\/www.fda.gov\/ohrms\/dockets\/DOCKETS\/95s0316\/95s\u20100316\u2010rpt0134\u201012\u2010Section\u2010Six\u201004\u2010Attachment\u2010C\u2010vol98.pdfin U. 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