{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:17:30Z","timestamp":1791490650740,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T00:00:00Z","timestamp":1442361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T00:00:00Z","timestamp":1442361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Soybean oil\u2013based intravenous fat emulsion (IVFE) administered to preterm neonates can induce oxidative stress and inflammatory response, which are associated with severe complications of prematurity. This study aimed to test the hypothesis that administration of medium\u2010chain triglyceride (MCT)\/\u03c9\u20103 polyunsaturated fatty acid (PUFA)\u2013enriched IVFE in preterm neonates is associated with a cytokine and fatty acid (FA) profile consistent with attenuated inflammatory response. <jats:italic>Patients\/Methods:<\/jats:italic> In a double\u2010blind randomized study, 60 preterm neonates (gestational age 26\u201332 weeks) were randomized to receive either MCT\/\u03c9\u20103 PUFA\u2010enriched IVFE (intervention group) or soybean oil\u2013based IVFE (control group). Serum biochemistry, tumor necrosis factor (TNF)\u2013\u03b1, interleukin (IL)\u20136, IL\u20108, \u03b1\u2010tocopherol, and FAs were assessed at baseline, on day of life 15, and day of life 30 or at the end of intervention. <jats:italic>Results:<\/jats:italic> All cytokine levels changed significantly across the 3 time points, whereas the type of IVFE had a significant effect on final IL\u20106 and IL\u20108 levels, which were lower in the intervention group. The difference in final IL\u20106 and IL\u20108 levels remained significant after controlling for bronchopulmonary dysplasia and\/or infection. \u03b1\u2010Tocopherol and FA values changed significantly over time. MCT\/\u03c9\u20103 PUFA\u2010enriched IVFE administration was associated with significantly higher \u03b1\u2010tocopherol, eicosapentaenoic acid, docosahexaenoic acid, and \u03c9\u20103 PUFAs and lower linolenic acid, total PUFA, and \u03c9\u20106\/\u03c9\u20103 PUFA values compared with soybean oil\u2013based IVFE. Both IVFEs were well tolerated. <jats:italic>Conclusion:<\/jats:italic> Compared with the soybean oil\u2013based IVFE, the MCT\/\u03c9\u20103 PUFA\u2010enriched IVFE is associated with a more favorable cytokine and FA profile consistent with attenuated inflammatory response in preterm neonates.<\/jats:p>","DOI":"10.1177\/0884533615602011","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T23:38:22Z","timestamp":1442446702000},"page":"235-244","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":58,"title":["Parenteral MCT\/\u03c9\u20103 Polyunsaturated Fatty Acid\u2013Enriched Intravenous Fat Emulsion Is Associated With Cytokine and Fatty Acid Profiles Consistent With Attenuated Inflammatory Response in Preterm 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