{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:41:40Z","timestamp":1773200500608,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>This study evaluated the effect of an immune\u2010modulatory diet on patients with gastric cancer and identified the parameters associated with postoperative outcomes. This was a single\u2010arm prospective intervention study. At baseline, patients were assessed for nutrition (Patient\u2010Generated Subjective Global Assessment), inflammatory markers (albumin, C\u2010reactive protein, and interleukin 6 [IL\u20106]), and immune markers (percentage NK, CD4, CD8, and CD4:CD8 ratio); they also received nutrition counseling and high\u2010calorie\/protein supplement. A week before surgery, they were assessed for nutrition and inflammatory\/immune markers and started on an immune\u2010modulatory supplement until the day before surgery, when they were evaluated again. On the second postoperative day, patients were assessed for inflammatory\/immune parameters, and a final nutrition evaluation was performed until the day of discharge. Complications were recorded daily and up to 30 days after discharge. Thirty\u2010seven patients (60 \u00b1 10 years old) were included, and 57% were classified as malnourished. Maintenance of nutrition and immune parameters occurred throughout the study period, but we found a preoperative increase in C\u2010reactive protein (0.1\u20131.5 mg\/dL) and IL\u20106 (2.0\u201314.2 pg\/mL) and a postoperative increase in the CD4:CD8 ratio (2.3 \u00b1 1.0). Complications and death were seen in 35%, especially patients with higher preoperative IL\u20106 (2.2\u201346 pg\/mL), lower CD4:CD8 ratio (1.7 \u00b1 0.5), and lower protein (1.2 \u00b1 0.5 g\/kg\/d) and calorie intake (1552 \u00b1 584 kcal\/kg\/d). The high\u2010calorie\/protein supplementation with the immune\u2010modulating diet was able to maintain the nutrition and immune status of patients with gastric cancer.<\/jats:p>","DOI":"10.1177\/0884533616653807","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T15:42:41Z","timestamp":1466610161000},"page":"122-129","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["Nutrition and Immune\u2010Modulatory Intervention in Surgical Patients With Gastric Cancer"],"prefix":"10.1002","volume":"32","author":[{"given":"Viviane","family":"Dias Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivaldo","family":"Barroso de Pinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana","family":"Abdelhay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o P. 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