{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:28:05Z","timestamp":1781688485427,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nut in Clin Prac"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> In recent years, the number of patients with cancer has increased. These patients are prone to sarcopenia as a result of the decrease in muscle mass and muscle weakness that occur in cancer cachexia. Amino Index Cancer Screening is carried out to evaluate cancer cachexia risk by examining amino acid concentration and analyzing amino acid balance. <jats:italic>Methods:<\/jats:italic> We conducted a retrospective chart review of consecutive patients with unresectable advanced gastrointestinal cancer (stage IV) receiving chemotherapy treatment (December 2012\u2013September 2015) in an outpatient or in\u2010hospital setting at our institution (N = 46). Data included characteristics, psoas muscle area per computed tomography, and biochemical blood test and serum amino acid profiles. <jats:italic>Method 1:<\/jats:italic> Comparison of biomarkers between 2 groups: psoas muscle index change rate (\u0394PMI) decrease vs increase. <jats:italic>Method 2.1:<\/jats:italic> Correlation between \u0394PMI and biomarkers. <jats:italic>Method 2.2:<\/jats:italic> Multiple regression of \u0394PMI and biomarkers. <jats:italic>Results:<\/jats:italic> EAA\/TAA ratio (essential amino acids\/total amino acids) in the decrease group was significantly higher than that in the increase group. Among all parameters, serum C\u2010reactive protein (CRP), leucine, and isoleucine were negatively related to \u0394PMI (correlation coefficients = \u22120.604, \u22120.540, \u22120.518; <jats:italic>P<\/jats:italic> = .004, .011, .016, respectively). On multiple regression analysis, serum CRP value was strongly related to \u0394PMI (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.452, \u03b2 = \u22120.672, <jats:italic>P<\/jats:italic> = .001). <jats:italic>Conclusions:<\/jats:italic> Higher serum EAA\/TAA ratio and CRP were associated with depletion in psoas muscle area, which led to a diagnosis of sarcopenia, in patients with advanced gastrointestinal cancers. These parameters at baseline could be predictors of cancer cachexia.<\/jats:p>","DOI":"10.1177\/0884533617724742","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T18:34:41Z","timestamp":1504031681000},"page":"645-651","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["High Serum Essential Amino Acids as a Predictor of Skeletal Muscle Depletion in Patients With Cachexia and Advanced Gastrointestinal Cancers"],"prefix":"10.1002","volume":"32","author":[{"given":"Moeko","family":"Kitagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Haji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyoshi","family":"Amagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Cancer Research UK.World cancer factsheet.http:\/\/publications.cancerresearchuk.org\/downloads\/product\/CS_REPORT_WORLD.pdf. 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