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Destination therapy with a ventricular assist device is the closest toward approaching clinical reality but has been plagued with problems of infection and stroke. The purpose of this review is to summarize recent developments in the field that may broaden the clinical impact of heart transplantation. For example, novel methods of cardiac preservation are being designed to safely evaluate and utilize \u201cextended criteria\u201d donors. Surgical techniques and medical management have reduced the incidence of postoperative right heart failure, and immunosuppressive regimens promise to limit chronic graft vascular disease.<\/jats:p>","DOI":"10.1177\/0885066603259012","type":"journal-article","created":{"date-parts":[[2004,4,21]],"date-time":"2004-04-21T19:33:37Z","timestamp":1082576017000},"page":"3-12","source":"Crossref","is-referenced-by-count":19,"title":["Heart Transplantation"],"prefix":"10.1177","volume":"19","author":[{"given":"Robert S.","family":"Poston","sequence":"first","affiliation":[{"name":"Division of Cardiac Surgery, N4W94 22 S. Greene St., Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartley P.","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,1,1]]},"reference":[{"key":"atypb1","unstructured":"1. Poston RS, Hussain S, Source D, et al. 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