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Plasmodium falciparum malaria and to some extent malaria caused by other species of Plasmodium can lead to many complications such as acute respiratory distress syndrome (ARDS), cerebral malaria, acute renal failure, severe anemia, thrombocytopenia, and bleeding complications. About 10% of patients with severe malaria die, usually as a result of multiorgan dysfunction. Critical care physicians should be aware of the complications and management of severe malaria. There has been significant progress in the understanding of pathogenesis of severe malaria over the last decade. Effective management of severe malaria includes early suspicion, prompt diagnosis, early institution of appropriate antimalarial chemotherapy, and supportive care, preferably in an intensive care unit. In this article, we review the different manifestations of severe malaria as relevant to critical care physicians and discuss the principles of laboratory diagnosis and management.<\/jats:p>","DOI":"10.1177\/0885066609356052","type":"journal-article","created":{"date-parts":[[2009,12,14]],"date-time":"2009-12-14T20:22:44Z","timestamp":1260822164000},"page":"93-103","source":"Crossref","is-referenced-by-count":35,"title":["Critical Care Aspects of Malaria"],"prefix":"10.1177","volume":"25","author":[{"given":"Pralay K.","family":"Sarkar","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine, North Shore University Hospital, North Shore Long Island Jewish Health System, New York, Long Island Jewish Medical Center, North Shore Long Island Jewish Health System, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Ahluwalia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dayananda 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