{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:13:18Z","timestamp":1777853598028,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T00:00:00Z","timestamp":1359417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Objective:<\/jats:title>\n To describe an extreme presentation of the chylomicronemia syndrome resulting in multiorgan system dysfunction.<\/jats:p>\n <\/jats:sec>\n \n Patient:<\/jats:title>\n A 40-year-old African American male with no past medical history presented with multiorgan system dysfunction manifested by acute respiratory failure and acute kidney injury. He was noted to have very-high triglyceride levels (>5000 mg\/dL) at admission.<\/jats:p>\n <\/jats:sec>\n \n Interventions:<\/jats:title>\n An echocardiogram showed normal cardiac function. Amylase and lipase were normal. We confirmed the chylomicronemia syndrome with a triglyceride assay. The associated hyperviscosity was treated with plasmapheresis to reduce the plasma triglyceride level.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n After 3 sessions of plasmapheresis, his triglyceride levels were significantly reduced, his oxygenation improved, and his acute kidney injury resolved. He was successfully extubated on day 7 of the intensive care unit stay. His diabetes and hypertriglyceridemia were newly diagnosed and drug therapy was instituted with home discharge on day 14.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Severe chylomicronemia can cause multiorgan system dysfunction related to hyperviscosity. Early institution of plasmapheresis to reduce the triglyceride-rich lipoproteins can improve tissue perfusion and prevent further organ damage.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/0885066613475425","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T21:29:33Z","timestamp":1359581373000},"page":"175-178","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Multiorgan System Dysfunction in the Chylomicronemia Syndrome"],"prefix":"10.1177","volume":"29","author":[{"given":"Rahul G.","family":"Argula","sequence":"first","affiliation":[{"name":"Division of Pulmonary & Critical Care Medicine, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlie","family":"Strange","sequence":"additional","affiliation":[{"name":"Division of Pulmonary & Critical Care Medicine, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milos N.","family":"Budisavljevic","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,1,29]]},"reference":[{"key":"bibr1-0885066613475425","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.10.004"},{"key":"bibr2-0885066613475425","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31430-4"},{"key":"bibr3-0885066613475425","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00643-X"},{"key":"bibr4-0885066613475425","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70025-6"},{"key":"bibr5-0885066613475425","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.3.744"},{"key":"bibr6-0885066613475425","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107001-00016"},{"key":"bibr7-0885066613475425","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2005.02.036"},{"key":"bibr8-0885066613475425","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872001001200002"},{"key":"bibr9-0885066613475425","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7067.1265"},{"key":"bibr10-0885066613475425","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41211-8"},{"key":"bibr11-0885066613475425","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2005.11.009"},{"key":"bibr12-0885066613475425","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.1999.00158.x"},{"key":"bibr13-0885066613475425","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9315-x"}],"container-title":["Journal of Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885066613475425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0885066613475425","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885066613475425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:54:55Z","timestamp":1777503295000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0885066613475425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,29]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1177\/0885066613475425"],"URL":"https:\/\/doi.org\/10.1177\/0885066613475425","relation":{},"ISSN":["0885-0666","1525-1489"],"issn-type":[{"value":"0885-0666","type":"print"},{"value":"1525-1489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,29]]}}}