{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:14:05Z","timestamp":1777853645755,"version":"3.51.4"},"reference-count":132,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T00:00:00Z","timestamp":1410739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>The management of critically ill patients with end-stage liver disease can be challenging due to the vulnerability of this population and the wide-ranging complications of the disease. This review proposes an approach based on the major organ systems affected, to provide a framework for managing the most common complications. Although considerable practice variation exists, a focus on the evidence behind the most common practices will ensure the development of the optimal skillset to appropriately manage this disease.<\/jats:p>","DOI":"10.1177\/0885066614551144","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T03:19:29Z","timestamp":1410837569000},"page":"94-103","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Management of Complications of End-Stage Liver Disease in the Intensive Care Unit"],"prefix":"10.1177","volume":"31","author":[{"given":"Jeffrey D.","family":"DellaVolpe","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Garavaglia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy & Therapeutics, Transplant Intensive Care Unit, UPMC Presbyterian Shadyside, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Director Multidisciplinary Acute Care Research Organization, University of Pittsburgh Medical Center, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"bibr1-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22269"},{"key":"bibr2-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.02.010"},{"key":"bibr3-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181f3dea9"},{"key":"bibr4-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2008.07.007"},{"key":"bibr5-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.26522"},{"key":"bibr6-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80144-5"},{"key":"bibr7-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.31250"},{"key":"bibr8-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22846"},{"key":"bibr9-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.116"},{"issue":"3","key":"bibr10-0885066614551144","first-page":"160","volume":"24","author":"Qureshi MO","year":"2014","journal-title":"Am J Med"},{"key":"bibr11-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.07.045"},{"key":"bibr12-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011170"},{"key":"bibr13-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07467.x"},{"key":"bibr14-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04468.x"},{"key":"bibr15-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1000850"},{"key":"bibr16-0885066614551144","doi-asserted-by":"publisher","DOI":"10.2165\/10898630-000000000-00000"},{"key":"bibr17-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38048.506134.EE"},{"key":"bibr18-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70239-7"},{"key":"bibr19-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.03.023"},{"key":"bibr20-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42644"},{"issue":"25","key":"bibr21-0885066614551144","first-page":"2424","volume":"362","author":"Xue T","year":"2010","journal-title":"N Engl J Med"},{"key":"bibr22-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K436"},{"key":"bibr23-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/236963"},{"key":"bibr24-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.219"},{"key":"bibr25-0885066614551144","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S30675"},{"key":"bibr26-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcp152"},{"key":"bibr27-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31608-4"},{"key":"bibr28-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90587-9"},{"key":"bibr29-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2006.01.021"},{"key":"bibr30-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.063735"},{"key":"bibr31-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300112"},{"key":"bibr32-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(03)00587-6"},{"key":"bibr33-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9073-9"},{"key":"bibr34-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.112177"},{"key":"bibr35-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-013-0610-1"},{"key":"bibr36-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-15"},{"issue":"2","key":"bibr37-0885066614551144","first-page":"G537","volume":"273","author":"Ward CA","year":"1997","journal-title":"Am J Physiol"},{"key":"bibr38-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.107177"},{"issue":"8","key":"bibr39-0885066614551144","first-page":"1181","volume":"57","author":"Thalheimer U","year":"2008","journal-title":"Gut"},{"key":"bibr40-0885066614551144","doi-asserted-by":"crossref","unstructured":"Jeppesen JB, Mortensen C, Bendtsen F, M\u00f8ller S. Lactate metabolism in chronic liver disease. 2013;73 (4):293\u2013299.","DOI":"10.3109\/00365513.2013.773591"},{"key":"bibr41-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198909000-00004"},{"key":"bibr42-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1979.tb00903.x"},{"key":"bibr43-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1007\/BF02396585"},{"key":"bibr44-0885066614551144","volume-title":"Septic Shock: Proceedings of a Workshop","author":"Strawitz Joseph George","year":"1965"},{"key":"bibr45-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000132904.35713.A7"},{"key":"bibr46-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00755-3"},{"key":"bibr47-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2006.035915"},{"key":"bibr48-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(97)70220-8"},{"key":"bibr49-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2004.12.006"},{"key":"bibr50-0885066614551144","doi-asserted-by":"crossref","first-page":"742A","DOI":"10.1016\/S0168-8278(98)80305-X","volume":"28","author":"Sood G","year":"1998","journal-title":"Hepatology"},{"key":"bibr51-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.7519"},{"key":"bibr52-0885066614551144","first-page":"255","author":"Mandell Mercedes Susan","year":"2012","journal-title":"Springer New York"},{"key":"bibr53-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318211fdc4"},{"key":"bibr54-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90589-8"},{"key":"bibr55-0885066614551144","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-7-199504010-00008"},{"issue":"7","key":"bibr56-0885066614551144","first-page":"521","volume":"122","author":"Fallon MB","year":"1995","journal-title":"Hepatology"},{"key":"bibr57-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70302-6"},{"key":"bibr58-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.2.515"},{"key":"bibr59-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.2.500"},{"key":"bibr60-0885066614551144","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-9-200011070-00012"},{"key":"bibr61-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2003.00033.x"},{"key":"bibr62-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.21287"},{"key":"bibr63-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16107-2"},{"key":"bibr64-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50060"},{"key":"bibr65-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2000.6356"},{"key":"bibr66-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20016"},{"key":"bibr67-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040291"},{"key":"bibr68-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00030206"},{"key":"bibr69-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.01.017"},{"key":"bibr70-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00217-X"},{"key":"bibr71-0885066614551144","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-64-2-341"},{"key":"bibr72-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400120029005"},{"key":"bibr73-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007200"},{"key":"bibr74-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1980.01380090091022"},{"issue":"9","key":"bibr75-0885066614551144","first-page":"1520","volume":"89","author":"Strauss RM","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"bibr76-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250611"},{"key":"bibr77-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230122"},{"key":"bibr78-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198100031-00016"},{"key":"bibr79-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)91007-9"},{"issue":"2","key":"bibr80-0885066614551144","first-page":"234","volume":"93","author":"Gin\u00e9s P","year":"1987","journal-title":"N Engl J Med"},{"key":"bibr81-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.0330477"},{"key":"bibr82-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0901512"},{"key":"bibr83-0885066614551144","first-page":"92238","volume":"46","author":"GarciaTsao G","year":"2007","journal-title":"Hepatology"},{"key":"bibr84-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)91166-4"},{"issue":"1","key":"bibr85-0885066614551144","first-page":"S68S92","volume":"48","author":"Bosch J","year":"2008","journal-title":"J Hepatol"},{"issue":"1","key":"bibr86-0885066614551144","first-page":"141","volume":"32","author":"Jaime B","year":"2000","journal-title":"J Hepatol"},{"key":"bibr87-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21907"},{"key":"bibr88-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9352866"},{"key":"bibr89-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211801"},{"key":"bibr90-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20339"},{"key":"bibr91-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.31354"},{"key":"bibr92-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440104"},{"key":"bibr93-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2009.03.008"},{"key":"bibr94-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.12.005"},{"key":"bibr95-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.22451"},{"key":"bibr96-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.147"},{"key":"bibr97-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.12.005"},{"key":"bibr98-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70478-5"},{"key":"bibr99-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.78"},{"issue":"3","key":"bibr100-0885066614551144","first-page":"323","volume":"148","author":"Terblanche J","year":"1979","journal-title":"Surg Gynecol Obstet"},{"key":"bibr101-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199206043262304"},{"key":"bibr102-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91090-5"},{"issue":"2","key":"bibr103-0885066614551144","first-page":"CD002907","author":"Soares-Weiser K","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr104-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290608"},{"issue":"1","key":"bibr105-0885066614551144","first-page":"142","volume":"32","author":"Rimola A","year":"2000","journal-title":"International Ascites Club. J Hepatol"},{"key":"bibr106-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.07.010"},{"key":"bibr107-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8608893"},{"key":"bibr108-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910102"},{"key":"bibr109-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90213-9"},{"key":"bibr110-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6681.1158"},{"key":"bibr111-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14903-3"},{"key":"bibr112-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90031-7"},{"key":"bibr113-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr736"},{"key":"bibr114-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230122"},{"key":"bibr115-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0809139"},{"key":"bibr116-0885066614551144","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3194"},{"key":"bibr117-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20189"},{"key":"bibr118-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14903-3"},{"key":"bibr119-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007252"},{"key":"bibr120-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-001-0051-2"},{"key":"bibr121-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1186\/cc12687"},{"key":"bibr122-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1007\/BF02600149"},{"key":"bibr123-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840020402"},{"key":"bibr124-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908053410603"},{"key":"bibr125-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20066"},{"key":"bibr126-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840080107"},{"key":"bibr127-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2769-8"},{"key":"bibr128-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23264"},{"key":"bibr129-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067373"},{"key":"bibr130-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21352"},{"key":"bibr131-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2769-8"},{"key":"bibr132-0885066614551144","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"}],"container-title":["Journal of Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885066614551144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0885066614551144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885066614551144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:55:30Z","timestamp":1777503330000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0885066614551144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,15]]},"references-count":132,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1177\/0885066614551144"],"URL":"https:\/\/doi.org\/10.1177\/0885066614551144","relation":{},"ISSN":["0885-0666","1525-1489"],"issn-type":[{"value":"0885-0666","type":"print"},{"value":"1525-1489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,15]]}}}