{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:14:10Z","timestamp":1777853650087,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>As patients recover from their critical illness, the focus of intensive care unit (ICU) care becomes rehabilitation. Fatigue, excessive daytime somnolence (EDS), and depression can delay their recovery and potentially worsen outcomes. Psychostimulants, particularly modafinil (Provigil), have been shown to alleviate some of these symptoms in various patient populations, and as clinical trials are underway exploring this novel use of the drug, we present a case series of 3 patients in our institution\u2019s Thoracic Surgery Intensive Care Unit. Our 3 patients were chosen as a result of their fatigue, EDS, and\/or depression, which prolonged their ICU stay and precluded them from participating in physical therapy, an integral component of the rehabilitative process. The patients were given 200 mg of modafinil each morning to increase patient wakefulness, encourage their participation, and enable a more restful sleep during the night. Although the drug was undoubtedly not the sole reason why our patients became more active, the temporal relationship between starting the drug and our patients\u2019 clinical improvement makes it likely that it contributed. Based on our observations with these patients, the known effects of modafinil, its safety profile, and the published experiences of others, we believe that modafinil has potential benefits when utilized in some critically ill patients and that the consequences of delayed patient recovery and a prolonged ICU stay may outweigh the risks of potential modafinil side effects.<\/jats:p>","DOI":"10.1177\/0885066615571899","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T04:13:24Z","timestamp":1424924004000},"page":"142-145","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The Use of Modafinil in the Intensive Care Unit"],"prefix":"10.1177","volume":"31","author":[{"given":"Michal","family":"Gajewski","sequence":"first","affiliation":[{"name":"Surgical Critical Care, Brigham and Women\u2019s Hospital, Boston, MA, USA"},{"name":"Department of Anesthesiology, New Jersey Medical School, Rutgers University, Newark, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Weinhouse","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care, Brigham and Women\u2019s Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,2,24]]},"reference":[{"key":"bibr1-0885066615571899","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60658-9"},{"key":"bibr2-0885066615571899","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000251130.69568.87"},{"key":"bibr3-0885066615571899","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318180b90e"},{"key":"bibr4-0885066615571899","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a38937"},{"key":"bibr5-0885066615571899","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31820ab4f6"},{"key":"bibr6-0885066615571899","unstructured":"MD Anderson Cancer Center. Single Agent Armodafinil for Patient-Reported Fatigue [Internet]. Bethesda, MD: National Library of Medicine; 2000. Web site. http:\/\/clinicaltrials.gov\/show\/NCT01330446. Accessed September 4, 2014. NLM Identifier: NCT013304."},{"key":"bibr7-0885066615571899","unstructured":"Sheba Medical Center. Fatigue Treatment Using Provigil [Internet]. Bethesda, MD: National Library of Medicine; 2000. Web site. http:\/\/clinicaltrials.gov\/show\/NCT00220506. Accessed September 4, 2014. NLM Identifier: NCT00220506."},{"key":"bibr8-0885066615571899","unstructured":"Joffe H; Massachusetts General Hospital. Effect of Nuvigil on Fatigue [Internet]. Bethesda, MD: National Library of Medicine; 2000. Web site. http:\/\/clinicaltrials.gov\/show\/NCT01460628. Accessed September 4, 2014. NLM Identifier: NCT01460628."},{"key":"bibr9-0885066615571899","unstructured":"Weinhouse GL; Brigham and Women\u2019s Hospital. Modafinil Versus Placebo for Hypoactive Delirium in the Critically Ill [Internet]. Bethesda, MD: National Library of Medicine; 2000. Web site. http:\/\/clinicaltrials.gov\/show\/NCT02028260. Accessed September 4, 2014. NLM Identifier: NCT02028260."},{"key":"bibr10-0885066615571899","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0406"},{"issue":"3","key":"bibr11-0885066615571899","first-page":"349","volume":"3","author":"Gerrard P","year":"2007","journal-title":"Neuropsychiatr Dis Treat"},{"key":"bibr12-0885066615571899","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200868130-00003"},{"issue":"129","key":"bibr13-0885066615571899","first-page":"1","volume":"4","author":"Wisor J","year":"2013","journal-title":"Front Neurol"},{"key":"bibr14-0885066615571899","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.7.1.99"},{"key":"bibr15-0885066615571899","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00353-3"},{"issue":"3","key":"bibr16-0885066615571899","first-page":"183","volume":"9","author":"Saletu B","year":"1989","journal-title":"Int J Clin Pharmacol Res"},{"issue":"10","key":"bibr17-0885066615571899","first-page":"1268","volume":"39","author":"Saletu B","year":"1989","journal-title":"Arzneimittelforschung"},{"key":"bibr18-0885066615571899","unstructured":"Cephalon, Inc. 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