{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:14:25Z","timestamp":1777853665615,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Although generally safe and effective, one of the unique properties of linezolid is its weak inhibitory effect on monoamine oxidase. As such, it may interact with other medications that act through the adrenergic or serotonergic systems, including selective-serotonin reuptake inhibitors and vasoactive agents. We present a 3-month-old infant who was being treated with dopamine to maintain mean arterial pressure during mechanical ventilation following viral-induced respiratory failure. Hypertension and tachycardia developed during the administration of linezolid on two separate occasions. The physiology of catecholamine metabolism is reviewed including the role of the monoamine oxidase system. The potential interaction between linezolid and vasoactive agents such as dopamine is discussed.<\/jats:p>","DOI":"10.1177\/0885066615627777","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T20:23:39Z","timestamp":1455135819000},"page":"490-492","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Augmentation of the Inotropic Effects of Dopamine Following Linezolid Administration in an Infant"],"prefix":"10.1177","volume":"31","author":[{"given":"Marlina E.","family":"Lovett","sequence":"first","affiliation":[{"name":"Division of Pediatric Critical Care, Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Estrada","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Sargel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph D.","family":"Tobias","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA"},{"name":"Department of Anesthesiology & Pain Medicine, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Department of Anesthesiology & Pain Medicine, The Ohio State University College of Medicine, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"bibr1-0885066615627777","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161040-00008"},{"key":"bibr2-0885066615627777","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(09)60009-8"},{"key":"bibr3-0885066615627777","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1504300507"},{"key":"bibr4-0885066615627777","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R604"},{"key":"bibr5-0885066615627777","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.2.269"},{"key":"bibr6-0885066615627777","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.77a.09103"},{"key":"bibr7-0885066615627777","doi-asserted-by":"publisher","DOI":"10.1177\/070674378703200915"},{"key":"bibr8-0885066615627777","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(85)72877-0"},{"key":"bibr9-0885066615627777","doi-asserted-by":"publisher","DOI":"10.1345\/aph.19221"},{"key":"bibr10-0885066615627777","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5544.75"},{"key":"bibr11-0885066615627777","doi-asserted-by":"publisher","DOI":"10.1177\/00912700122010302"}],"container-title":["Journal of Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885066615627777","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0885066615627777","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885066615627777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:55:41Z","timestamp":1777503341000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0885066615627777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,7]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1177\/0885066615627777"],"URL":"https:\/\/doi.org\/10.1177\/0885066615627777","relation":{},"ISSN":["0885-0666","1525-1489"],"issn-type":[{"value":"0885-0666","type":"print"},{"value":"1525-1489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,7]]}}}