{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:15:28Z","timestamp":1779214528489,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Clinically unapparent microcirculatory impairment is common and has a negative impact on septic shock, but specific therapy is not established so far. This prospective observational study aimed at identifying candidate parameters for microcirculatory-guided hemodynamic therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>:<\/jats:title>\n                    <jats:p>NCT01530932.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Microcirculatory flow and postcapillary venous oxygen saturation were detected during vaso-occlusive testing (VOT) on days 1 (T0), 2 (T24), and 4 (T72) in 20 patients with septic shock at a surgical intensive care unit using a laser Doppler spectrophotometry system (O2C).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Reperfusional maximal venous capillary oxygen saturation (SvcO\n                      <jats:sub>2<\/jats:sub>\n                      max) showed negative correlations with Simplified Acute Physiology Score II (SAPSII)\/Sequential Organ Failure Assessment (SOFA) score, norepinephrine dosage, and lactate concentration and showed positive correlations with cardiac index (CI). At T24 and T72, SvcO\n                      <jats:sub>2<\/jats:sub>\n                      max was also inversely linked to fluid balance. With respect to any predictive value, SvcO\n                      <jats:sub>2<\/jats:sub>\n                      max and CI determined on day 1 (T0) were negatively correlated with SAPS II\/SOFA on day 4 (T72). Moreover, SvcO\n                      <jats:sub>2<\/jats:sub>\n                      max measured on day 1 or day 2 was negatively correlated with cumulated fluid balance on day 4 ( r= \u2212.472, P &lt; .05 and r = \u2212.829, P &lt; .001). By contrast, CI neither on day 1 nor on day 2 was correlated with cumulated fluid balance on day 4 ( r = \u2212.343, P = .17 and r = \u2212.365, P = .15).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      In patients with septic shock, microcirculatory reserve as assessed by SvcO\n                      <jats:sub>2<\/jats:sub>\n                      max following VOT was impaired and negatively correlated with severity of illness and fluid balance. In contrast to CI, SvcO\n                      <jats:sub>2<\/jats:sub>\n                      max determined on day 1 or day 2 was significantly negatively correlated with cumulative fluid balance on day 4. Therefore, early microcirculatory measurement of SvcO\n                      <jats:sub>2<\/jats:sub>\n                      max might be superior to CI in guidance of sepsis therapy to avoid fluid overload. This has to be addressed in future clinical studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0885066616671689","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T20:59:00Z","timestamp":1475182740000},"page":"256-266","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of Microcirculation, Macrocirculation, and Severity of Illness in Septic Shock: A Prospective Observational Study to Identify Microcirculatory Targets Potentially Suitable for Guidance of Hemodynamic Therapy"],"prefix":"10.1177","volume":"33","author":[{"given":"Timo","family":"Sturm","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Surgical Intensive Care Medicine, University Medical Centre Mannheim, Mannheim, 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