{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:20:26Z","timestamp":1789554026796,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Severe acute respiratory distress syndrome (ARDS) has a high mortality, and there is limited knowledge about management of severe ARDS refractory to standard therapy. Early evidence suggests that therapeutic hypothermia (TH) could be a viable treatment for acute respiratory failure. We present 2 cases where TH was successfully used to manage refractory ARDS on extracorporeal membrane oxygenation (ECMO) and a review of the literature around TH and acute respiratory failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We present 2 cases of ARDS secondary to H1N1 influenza and human metapneumovirus. Both patients were treated with the current evidence-based therapy for ARDS. Venovenous ECMO was used in both patients for refractory hypoxemia. Therapeutic hypothermia was applied for 24 hours with improved oxygenation. We did a review of the literature summarizing 38 patients in 10 publications where TH was successfully utilized in the treatment of acute respiratory failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Therapeutic hypothermia may be a viable salvage therapy for ARDS refractory to the current evidence-based therapy but needs further evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0885066617701117","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T04:31:55Z","timestamp":1490589115000},"page":"460-464","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Is Therapeutic Hypothermia for Acute Respiratory Distress Syndrome the Future?"],"prefix":"10.1177","volume":"32","author":[{"given":"Adam J.","family":"Hayek","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Baylor Scott & White Health, Temple, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heath D.","family":"White","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Baylor Scott & White Health, Temple, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shekhar","family":"Ghamande","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Baylor Scott & White Health, Temple, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Spradley","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Baylor Scott & White Health, Temple, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro C.","family":"Arroliga","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Baylor Scott & White Health, Temple, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,27]]},"reference":[{"key":"bibr1-0885066617701117","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0291"},{"key":"bibr2-0885066617701117","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050333"},{"key":"bibr3-0885066617701117","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"bibr4-0885066617701117","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.218"},{"key":"bibr5-0885066617701117","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062200"},{"key":"bibr6-0885066617701117","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005372"},{"key":"bibr7-0885066617701117","doi-asserted-by":"publisher","DOI":"10.1186\/cc12557"},{"key":"bibr8-0885066617701117","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214103"},{"key":"bibr9-0885066617701117","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61069-2"},{"key":"bibr10-0885066617701117","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4325-4"},{"issue":"1","key":"bibr11-0885066617701117","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1002\/ccd.24387","volume":"82","author":"O\u2019Gara 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