{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:17:42Z","timestamp":1787962662273,"version":"build-2784847793"},"reference-count":10,"publisher":"SAGE Publications","issue":"11-12","license":[{"start":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:00:00Z","timestamp":1499904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\u201cRules of thumb\u201d for the replacement of electrolytes, including magnesium, in critical care settings are used, despite minimal empirical validation of their ability to achieve a target serum concentration. This study\u2019s purpose was to evaluate the effectiveness and safety surrounding magnesium replacement in medically, critically ill patients with mild-to-moderate hypomagnesemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a single-center, retrospective, observational evaluation of episodes of intravenous magnesium replacement ordered for patients with mild-to-moderate hypomagnesemia (1.0-1.9 mEq\/L) admitted to a medical intensive care unit from May 2014 to April 2016. The primary effectiveness outcome, achievement of target serum magnesium concentration (\u22652 mEq\/L) compared to expected achievement using a \u201crule of thumb\u201d estimation that 1 g intravenous magnesium sulfate raises the magnesium concentration 0.15 mEq\/L, was tested using 1-sample z test. Logistic regression analysis was conducted to assess the effect of infusion rate on target achievement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 152 days on which magnesium replacements were provided for 72 patients, a follow-up serum magnesium concentration was checked within 24 hours in 89 (58.6%) episodes. Of these 89 episodes, serum magnesium concentration reached target in only 49 (59.8%) episodes compared to an expected 89 (100%; P &lt; .0001). There was no significant association between infusion rate and achievement of the target serum magnesium concentration (odds ratio: 0.962, 95% confidence interval: 0.411-2.256).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Medically, critically ill patients who received nonprotocolized magnesium replacement achieved the target serum magnesium concentration less frequently than the \u201crule of thumb\u201d estimation predicted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0885066617720631","type":"journal-article","created":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T05:59:50Z","timestamp":1514699990000},"page":"967-972","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Effectiveness and Safety of Magnesium Replacement in Critically Ill Patients Admitted to the Medical Intensive Care Unit in an Academic Medical Center: A Retrospective, Cohort Study"],"prefix":"10.1177","volume":"34","author":[{"given":"Drayton A.","family":"Hammond","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Rush University Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Stojakovic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Central Arkansas Veterans Healthcare System, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan","family":"Kathe","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, University of Arkansas for Medical Sciences College of Pharmacy, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mercy Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oktawia A.","family":"Clem","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, University of Arkansas for Medical Sciences College of Pharmacy, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Erbach","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, University of Arkansas for Medical Sciences College of Pharmacy, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarrod","family":"King","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, University of Arkansas for Medical Sciences College of Pharmacy, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,7,13]]},"reference":[{"key":"bibr1-0885066617720631","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007111194"},{"key":"bibr2-0885066617720631","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp040300"},{"key":"bibr3-0885066617720631","doi-asserted-by":"publisher","DOI":"10.1177\/0885066604271539"},{"key":"bibr4-0885066617720631","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2007.04.006"},{"issue":"2","key":"bibr5-0885066617720631","doi-asserted-by":"crossref","first-page":"96","DOI":"10.4212\/cjhp.v66i2.1231","volume":"66","author":"Couture J","year":"2013","journal-title":"Can J Hosp Pharm"},{"key":"bibr6-0885066617720631","first-page":"19","volume":"59","author":"Limaye CS","year":"2011","journal-title":"J Assoc Physicians India"},{"key":"bibr7-0885066617720631","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccn.2009.03.004"},{"key":"bibr8-0885066617720631","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2005.105"},{"key":"bibr9-0885066617720631","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2009.04.032"},{"issue":"1","key":"bibr10-0885066617720631","first-page":"217","volume":"5","author":"Balesteri FJ","year":"1985","journal-title":"Crit Care Clin"}],"container-title":["Journal of Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885066617720631","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0885066617720631","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885066617720631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:56:25Z","timestamp":1777503385000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0885066617720631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,13]]},"references-count":10,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1177\/0885066617720631"],"URL":"https:\/\/doi.org\/10.1177\/0885066617720631","relation":{},"ISSN":["0885-0666","1525-1489"],"issn-type":[{"value":"0885-0666","type":"print"},{"value":"1525-1489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,13]]}}}