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In contrast to various other pathologies requiring mechanical ventilation, acute asthma is generally associated with better outcomes. This review serves as a practical guide to the physician managing patients with severe acute asthma requiring mechanical ventilation. In addition to specifics relating to endotracheal intubation, we also discuss the interpretation of ventilator graphics, the recommended mode of ventilation, dynamic hyperinflation, permissive hypercapnia, as well as the role of extracorporeal membrane oxygenation and noninvasive mechanical ventilation.<\/jats:p>","DOI":"10.1177\/0885066617740079","type":"journal-article","created":{"date-parts":[[2017,11,5]],"date-time":"2017-11-05T22:58:54Z","timestamp":1509922734000},"page":"491-501","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":43,"title":["Mechanically Ventilating the Severe Asthmatic"],"prefix":"10.1177","volume":"33","author":[{"given":"Abdullah E.","family":"Laher","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Department of Critical Care, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean K.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,11,5]]},"reference":[{"key":"bibr1-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1353\/hpu.2014.0051"},{"key":"bibr2-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61444-5"},{"key":"bibr3-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200208-902SO"},{"key":"bibr4-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.5.1439"},{"key":"bibr5-0885066617740079","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2006.461"},{"key":"bibr6-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-011-8274-y"},{"key":"bibr7-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.3.607"},{"key":"bibr8-0885066617740079","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.124441"},{"key":"bibr9-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1080\/02770900801999090"},{"key":"bibr10-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-011-8273-z"},{"issue":"4","key":"bibr11-0885066617740079","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0272-5231(21)01164-3","volume":"16","author":"Cherniack RM","year":"1995","journal-title":"Clin Chest Med"},{"issue":"11","key":"bibr12-0885066617740079","first-page":"S1","volume":"161","author":"Boulet LP","year":"1999","journal-title":"CMAJ"},{"key":"bibr13-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000257115.02573.FC"},{"key":"bibr14-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-013-0383-1"},{"key":"bibr15-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1186\/cc1451"},{"key":"bibr16-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(96)70319-0"},{"key":"bibr17-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(87)80688-1"},{"key":"bibr18-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1007\/BF01690555"},{"key":"bibr19-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2005.030635"},{"key":"bibr20-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199903000-00025"},{"key":"bibr21-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1177\/0885066614523100"},{"key":"bibr22-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1177\/0885066607299525"},{"key":"bibr23-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2015.08.002"},{"issue":"2","key":"bibr24-0885066617740079","first-page":"142","volume":"17","author":"Scherzer D","year":"2012","journal-title":"J Pediatr Pharmacol Ther"},{"key":"bibr25-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1513\/pats.P09ST4"},{"key":"bibr26-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199511000-00012"},{"issue":"3","key":"bibr27-0885066617740079","doi-asserted-by":"crossref","first-page":"189","DOI":"10.7196\/SAMJ.6526","volume":"103","author":"Lalloo UG","year":"2013","journal-title":"S Afr Med J"},{"key":"bibr28-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.6.1627"},{"key":"bibr29-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.56"},{"key":"bibr30-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181f85759"},{"key":"bibr31-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1186\/cc4939"},{"key":"bibr32-0885066617740079","doi-asserted-by":"publisher","DOI":"10.1186\/cc3733"},{"key":"bibr33-0885066617740079","unstructured":"Rafanan A. 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