{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:15:56Z","timestamp":1780460156395,"version":"3.54.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL134625 (AA)"],"award-info":[{"award-number":["HL134625 (AA)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Respiratory variation in carotid artery peak systolic velocity (\u0394Vpeak) assessed by point-of-care ultrasound (POCUS) has been proposed as a noninvasive means to predict fluid responsiveness. We aimed to evaluate the ability of carotid \u0394Vpeak as assessed by novice physician sonologists to predict fluid responsiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study was conducted in 2 intensive care units. Spontaneously breathing, nonintubated patients with signs of volume depletion were included. Patients with atrial fibrillation\/flutter, cardiogenic, obstructive or neurogenic shock, or those for whom further intravenous (IV) fluid administration would be harmful were excluded. Three novice physician sonologists were trained in POCUS assessment of carotid \u0394Vpeak. They assessed the carotid \u0394Vpeak in study participants prior to the administration of a 500 mL IV fluid bolus. Fluid responsiveness was defined as a \u226510% increase in cardiac index as measured using bioreactance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eighty-six participants were enrolled, 50 (58.1%) were fluid responders. Carotid \u0394Vpeak performed poorly at predicting fluid responsiveness. Test characteristics for the optimum carotid \u0394Vpeak of 8.0% were: area under the receiver operating curve = 0.61 (95% CI: 0.48-0.73), sensitivity = 72.0% (95% CI: 58.3-82.56), specificity = 50.0% (95% CI: 34.5-65.5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Novice physician sonologists using POCUS are unable to predict fluid responsiveness using carotid \u0394Vpeak. Until further research identifies key limiting factors, clinicians should use caution directing IV fluid resuscitation using carotid \u0394Vpeak.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0885066620934392","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T05:36:30Z","timestamp":1593408990000},"page":"885-892","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Respiratory Variation in Carotid Artery Peak Systolic Velocity Is Unable to Predict Fluid Responsiveness in Spontaneously Breathing Critically Ill Patients When Assessed by Novice Physician Sonologists"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7887-243X","authenticated-orcid":false,"given":"Adeel","family":"Abbasi","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Warren Alpert 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lopardo","sequence":"additional","affiliation":[{"name":"Warren Alpert School of Medicine at Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Center for Biostatistics, Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland C.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Brown University School of Public Health, Providence, RI, USA"},{"name":"Department of Emergency Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell M.","family":"Levy","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department 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