{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:51:12Z","timestamp":1790319072675,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Little is known about hypoxemia surrounding endotracheal intubation in the critically ill. Thus, we sought to identify risk factors associated with peri-intubation hypoxemia and its effects\u2019 on the critically ill.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data from a multicenter, prospective, cohort study enrolling 1,033 critically ill adults who underwent endotracheal intubation across 16 medical\/surgical ICUs in the United States from July 2015-January 2017 were used to identify risk factors associated with peri-intubation hypoxemia and its effects on patient outcomes. We defined hypoxemia as any pulse oximetry \u2264 88% during and up to 30 minutes following endotracheal intubation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In the full analysis (n = 1,033), 123 (11.9%) patients experienced the primary outcome. Five risk factors independently associated with our outcome were identified on multiple logistic regression: cardiac related reason for endotracheal intubation (OR 1.67, [95% CI 1.04, 2.69]); pre-intubation noninvasive ventilation (OR 1.66, [95% CI 1.09, 2.54]); emergency intubation (OR 1.65, [95% CI 1.06, 2.55]); moderate-severe difficult bag-mask ventilation (OR 2.68, [95% CI 1.72, 4.19]); and crystalloid administration within the preceding 24 hours (OR 1.24, [95% CI 1.07, 1.45]; per liter up to 4 liters). Higher baseline S\n                      <jats:sub>p<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      was found to be protective (OR 0.93, [95% CI 0.91, 0.96]; per percent up to 97%). Consistent results were seen in a separate analysis on only stable patients (n = 921, 93 [10.1%]) (those without baseline hypoxemia \u2264 88%). Peri-intubation hypoxemia was associated with in-hospital mortality (OR 2.40, [95% CI 1.33, 4.31]; stable patients: OR 2.67, [95% CI 1.38, 5.17]) but not ICU length of stay (point estimate 0.9 days, [95% CI \u22121.0, 2.8 days]; stable patients: point estimate 1.5 days, [95% CI \u22120.4, 3.4 days]) after adjusting for age, body mass index, illness severity, airway related reason for intubation (i.e., acute respiratory failure), and baseline S\n                      <jats:sub>P<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Patients with pre-existing noninvasive ventilation and volume loading who were intubated emergently in the setting of hemodynamic compromise with bag-mask ventilation described as moderate-severe were at increased risk for peri-intubation hypoxemia. Higher baseline oxygenation was found to be protective against peri-intubation hypoxemia. Peri-intubation hypoxemia was associated with in-hospital mortality but not ICU length of stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>Clinicaltrials.gov identifier: NCT02508948 and Registered Report Identifier: RR2-10.2196\/11101.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0885066620962445","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T05:43:36Z","timestamp":1601531016000},"page":"1466-1474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Risk Factors for and Outcomes Associated With Peri-Intubation Hypoxemia: A Multicenter Prospective Cohort Study"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1051-098X","authenticated-orcid":false,"given":"Nathan J.","family":"Smischney","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA"},{"name":"HEModynamic and AIRway Management (HEMAIR) Study Group Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish K.","family":"Khanna","sequence":"additional","affiliation":[{"name":"Outcomes Research Consortium, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Department of Anesthesia, Section on Critical Care Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Brauer","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Aurora Health Care, Milwaukee, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee E.","family":"Morrow","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Creighton University, Omaha, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4723-4109","authenticated-orcid":false,"given":"Uchenna R.","family":"Ofoma","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Geisinger Health System, Danville, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Section of Pulmonary, Critical Care, and Sleep Medicine, Bridgeport Hospital\/Yale New Haven Health, Bridgeport, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayan","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakradhar","family":"Venkata","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Mercy Hospital, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care Medicine, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-5559","authenticated-orcid":false,"given":"Vikas","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Mayo Clinic, Scottsdale, AZ, USA. Ofoma is now with Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA; Kaufman is now with Division of Pulmonary, Critical Care, and Sleep Medicine, NYU School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"bibr1-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0964-z"},{"key":"bibr2-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1205-6"},{"key":"bibr3-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0975-9"},{"key":"bibr4-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001561"},{"key":"bibr5-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.06.007"},{"key":"bibr6-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.10.018"},{"key":"bibr7-0885066620962445","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.895919"},{"key":"bibr8-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2012.04.022"},{"key":"bibr9-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233852"},{"key":"bibr10-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201210-1851OC"},{"key":"bibr11-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000122825.04923.15"},{"key":"bibr12-0885066620962445","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.08.138"},{"key":"bibr13-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000233879.58720.87"},{"key":"bibr14-0885066620962445","doi-asserted-by":"publisher","DOI":"10.2196\/11101"},{"key":"bibr15-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201505-1019OC"},{"key":"bibr16-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916431"},{"key":"bibr17-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c5462"},{"key":"bibr18-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201802-118OC"},{"key":"bibr19-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1992.tb03479.x"},{"key":"bibr20-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0984-8"},{"key":"bibr21-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2475-6"},{"key":"bibr22-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3693-5"},{"key":"bibr23-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4601-3"},{"key":"bibr24-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-015-0044-1"},{"key":"bibr25-0885066620962445","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.138147"},{"key":"bibr26-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjem.2018.01.002"},{"key":"bibr27-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000284587.36541.7F"},{"key":"bibr28-0885066620962445","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01692"},{"key":"bibr29-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.11.022"},{"key":"bibr30-0885066620962445","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew055"},{"key":"bibr31-0885066620962445","doi-asserted-by":"publisher","DOI":"10.4266\/acc.2019.00717"},{"key":"bibr32-0885066620962445","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2017.013"},{"key":"bibr33-0885066620962445","doi-asserted-by":"crossref","unstructured":"Baker P. 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