{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:24:54Z","timestamp":1793193894406,"version":"4.5.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study the effect of hypoalbuminemia on short- and long-term mortality in Cardiac Intensive Care Unit (CICU) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We reviewed 12,418 unique CICU patients from 2007 to 2018. Hypoalbuminemia was defined as an admission albumin level &lt;3.5 g\/dL. Predictors of hospital mortality were identified using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We included 2,680 patients (22%) with a measured admission albumin level. The median age was 68 (39% females). Admission diagnoses included acute coronary syndrome, heart failure, cardiac arrest, and cardiogenic shock. The median albumin level was 3.4 g\/dL and 55% of patients had hypoalbuminemia. Hospital mortality occurred in 16%, and patients with hypoalbuminemia had higher hospital mortality (21% vs. 9%, adjusted OR 2.64, 95% CI 2.09-3.34, p &lt; 0.001). Albumin level was inversely associated with hospital mortality (adjusted OR 0.60 per 1 g\/dL higher albumin level, 95% CI 0.47-0.75, p &lt;0.001), with a stepwise increase in the hospital mortality at lower albumin levels. Post-discharge mortality was higher in hospital survivors with hypoalbuminemia, and increased as a function of lower albumin levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Hypoalbuminemia is common in CICU patients and associated with higher short- and long-term mortality. Progressively lower serum albumin was incrementally associated with higher hospital and post-discharge mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0885066620963875","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T05:59:12Z","timestamp":1601877552000},"page":"1475-1482","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Association Between Albumin Level and Mortality Among Cardiac Intensive Care Unit Patients"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7144-5280","authenticated-orcid":false,"given":"Mitchell","family":"Padkins","sequence":"first","affiliation":[{"name":"Mayo Clinic School of Graduate Medical Education, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Breen","sequence":"additional","affiliation":[{"name":"Mayo Clinic School of Graduate Medical Education, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandan","family":"Anavekar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Barsness","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kianoush","family":"Kashani","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA"},{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-2859","authenticated-orcid":false,"given":"Jacob C.","family":"Jentzer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"bibr1-0885066620963875","volume-title":"Hypoalbuminemia","author":"Gounden V","year":"2019"},{"key":"bibr2-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-012-0802-0"},{"key":"bibr3-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.07.020"},{"key":"bibr4-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.05.067"},{"key":"bibr5-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2001.0439"},{"key":"bibr6-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004085"},{"key":"bibr7-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2014.12.001"},{"key":"bibr8-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.474569"},{"key":"bibr9-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.01.015"},{"key":"bibr10-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.09.014"},{"key":"bibr11-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00455.x"},{"key":"bibr12-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-016-1453-2"},{"key":"bibr13-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23153"},{"key":"bibr14-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1177\/0300060518777349"},{"key":"bibr15-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.11.054"},{"key":"bibr16-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22954"},{"key":"bibr17-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e32835c46fd"},{"key":"bibr18-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.11.043"},{"key":"bibr19-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.05.012"},{"key":"bibr20-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000216"},{"key":"bibr21-0885066620963875","first-page":"975672","volume":"2013","author":"Harrison AM","year":"2013","journal-title":"Crit Care Res Pract"},{"key":"bibr22-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008169"},{"key":"bibr23-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2018.12.012"},{"key":"bibr24-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.08.011"},{"key":"bibr25-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.04.015"},{"key":"bibr26-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.04.038"},{"key":"bibr27-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01549-0"},{"key":"bibr28-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1177\/1099800419827600"},{"key":"bibr29-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105983"},{"key":"bibr30-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1177\/0885066616685300"},{"key":"bibr31-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.6.1619"},{"key":"bibr32-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0498"},{"key":"bibr33-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2018.1521557"},{"key":"bibr34-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.51.221"},{"key":"bibr35-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199304000-00017"},{"key":"bibr36-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113000"},{"key":"bibr37-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840120517"},{"key":"bibr38-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.06.024"},{"key":"bibr39-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025958"},{"key":"bibr40-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305727"},{"key":"bibr41-0885066620963875","doi-asserted-by":"publisher","DOI":"10.1177\/0885066617741873"}],"container-title":["Journal of Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885066620963875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0885066620963875","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885066620963875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:56:39Z","timestamp":1777503399000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0885066620963875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,5]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1177\/0885066620963875"],"URL":"https:\/\/doi.org\/10.1177\/0885066620963875","relation":{},"ISSN":["0885-0666","1525-1489"],"issn-type":[{"value":"0885-0666","type":"print"},{"value":"1525-1489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,5]]}}}