{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:14:39Z","timestamp":1784783679650,"version":"3.55.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p>Objective: The aim of this study was to develop evidence-based recommendations for the diagnosis and treatment of sepsis in children in low- and middle-income countries (LMICs), more specifically in Latin America. Design: A panel was formed consisting of 27 experts with experience in the treatment of pediatric sepsis and two methodologists working in Latin American countries. The experts were organized into 10 nominal groups, each coordinated by a member. Methods: A formal consensus was formed based on the modified Delphi method, combining the opinions of nominal groups of experts with the interpretation of available scientific evidence, in a systematic process of consolidating a body of recommendations. The systematic search was performed by a specialized librarian and included specific algorithms for the Cochrane Specialized Register, PubMed, Lilacs, and Scopus, as well as for OpenGrey databases for grey literature. The GRADEpro GDT guide was used to classify each of the selected articles. Special emphasis was placed on search engines that included original research conducted in LMICs. Studies in English, Spanish, and Portuguese were covered. Through virtual meetings held between February 2020 and February 2021, the entire group of experts reviewed the recommendations and suggestions. Result: At the end of the 12 months of work, the consensus provided 62 recommendations for the diagnosis and treatment of pediatric sepsis in LMICs. Overall, 60 were strong recommendations, although 56 of these had a low level of evidence. Conclusions: These are the first consensus recommendations for the diagnosis and management of pediatric sepsis focused on LMICs, more specifically in Latin American countries. The consensus shows that, in these regions, where the burden of pediatric sepsis is greater than in high-income countries, there is little high-level evidence. Despite the limitations, this consensus is an important step forward for the diagnosis and treatment of pediatric sepsis in Latin America.<\/jats:p>","DOI":"10.1177\/08850666211054444","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T09:33:06Z","timestamp":1637659986000},"page":"753-763","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Latin American Consensus on the Management of Sepsis in Children: Sociedad Latinoamericana de Cuidados Intensivos Pedi\u00e1tricos [Latin American Pediatric Intensive Care Society] (SLACIP) Task Force: Executive Summary"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2874-2949","authenticated-orcid":false,"given":"Jaime","family":"Fern\u00e1ndez-Sarmiento","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Cardioinfantil - Instituto de Cardiolog\u00eda, Universidad de la Sabana, CES Graduate School, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Carla","family":"De Souza","sequence":"additional","affiliation":[{"name":"Hospital Universitario da Universidad de S\u00e3o Paulo and Hospital S\u00edrio Liban\u00eas, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anacaona","family":"Martinez","sequence":"additional","affiliation":[{"name":"Universidad CES, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Nieto","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Cobos Medical Center, Chief Research Group GriBos, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"L\u00f3pez-Herce","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Hospital General Universitario Gregorio Mara\u00f1\u00f3n; Department of Public and Maternal-Infant Health, Universidad Complutense de Madrid, Red de Salud Maternoinfantil y del Desarrollo, Madrid, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Soares Lanziotti","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit & Research and Education Division\/Maternal and Child Health Postgraduate Program, Institute of Pediatrics, Federal University of Rio De Janeiro, Rio De Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Pilar","family":"Arias L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Hospital de Ni\u00f1os Ricardo Gutierrez, Programa SATI-Q, Sociedad Argentina de Terapia Intensiva, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werther Brunow","family":"De Carvalho","sequence":"additional","affiliation":[{"name":"Neonatology and Intensive Care Pediatrics, Department of Medical University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"The Latin America Sepsis Institute, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6973-6612","authenticated-orcid":false,"given":"Juan Camilo","family":"Jaramillo-Bustamante","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Intensive Care, Hospital General de Medell\u00edn, Universidad de Antioquia, Red Colaborativa Pedi\u00e1trica de Latinoam\u00e9rica (LARed Network), Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias e Innovacion en Medicina, Universidad del Desarrollo y Hospital El Carmen de Maipu, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Yock-Corrales","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Nacional de Ni\u00f1os \u201cDr. Carlos Saenz Herrera\u201d, CCSS, Pediatric Emergency Physician, San Jos\u00e9, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvina","family":"Ruvinsky","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital de Pediatr\u00eda Juan P. Garrahan, Latin American Society of Infectious Disease, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Munaico","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Hospital Nacional Edgardo Rebagliati Martins, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Pavlicich","sequence":"additional","affiliation":[{"name":"Hospital General Pedi\u00e1trico Ni\u00f1os de Acosta \u00d1u, Universidad Privada del Pac\u00edfico, Asunci\u00f3n, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Iramain","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Hospital de Cl\u00ednicas, Universidad Nacional de Asunci\u00f3n, Asunci\u00f3n, Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Patricia","family":"M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Complejo M\u00e9dico \u201cCHURUCA VISCA\u201d, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Yunge","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Cl\u00ednica Los Condes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Tonial","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Hospital S\u00e3o Lucas, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Cruces","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care, Hospital El Carmen de Maip\u00fa, Centro de Investigaci\u00f3n de Medicina Veterinaria, Facultad de Ciencias de la Vida, Universidad Andres Bello, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys","family":"Palacio","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit Ricardo Guti\u00e9rrez Children's Hospital, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Grela","sequence":"additional","affiliation":[{"name":"Universidad de la Rep\u00fablica, Centro Hospitalario Pereira Rossell, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sl\u00f6cker-Barrio","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Campos-Mi\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Hospital Metropolitano, Latin American Center for Clinical Research, Quito - Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Gonz\u00e1lez-Dambrauskas","sequence":"additional","affiliation":[{"name":"Red Colaborativa Pedi\u00e1trica de Latinoam\u00e9rica (LARed Network) - Montevideo, Uruguay. Specialized Pediatric Intensive Care, Casa de Galicia, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson L","family":"S\u00e1nchez-Pinto","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Chicago, IL, USA"},{"name":"Ann & Robert H. Lurie Children's Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Celiny Garc\u00eda","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Escola de Medicina, Servi\u00e7o de Medicina Intensiva e Emerg\u00eancia, Porto Alegre, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Jabornisky","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Facultad de Medicina, Universidad Nacional del Nordeste, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"issue":"92","key":"bibr1-08850666211054444","first-page":"7","volume":"22","author":"Martischang R","year":"2018","journal-title":"Crit Care"},{"key":"bibr2-08850666211054444","unstructured":"Torio CM, Moore BJ. National inpatient hospital costs: the most expensive conditions by payer, 2013. May, 2016. Available at: https:\/\/www.hcup-us.ahrq.gov\/reports\/statbriefs\/sb204-Most-Expensive-Hospital-Conditions.pdf Accessed November 2019."},{"key":"bibr3-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"bibr4-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.4839"},{"key":"bibr5-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002198"},{"key":"bibr6-08850666211054444","unstructured":"World Health Organization. WHO Report on the burden of endemic health care-associated infection worldwide. 2017\u201311-21 15:11:22 2011. Available at: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/80135\/9789241501507_eng.pdf?sequence\u2009=\u20091. Accessed November 2020."},{"key":"bibr7-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.160798"},{"key":"bibr8-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2157-z"},{"key":"bibr9-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000152"},{"key":"bibr10-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000699"},{"key":"bibr11-08850666211054444","volume-title":"Sepsis: Recognition, Diagnosis and Early Management","author":"National Institute for Health and Care Excellence","year":"2016"},{"key":"bibr12-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1055-x"},{"key":"bibr13-08850666211054444","unstructured":"Global Burden of Disease Collaborative Network. Global Burden of Disease Study 2017 (GBD 2017) Results. Seattle, United States: Institute for Health Metrics and Evaluation (IHME), 2018. Available at: http:\/\/www.healthdata.org\/sites\/default\/files\/files\/policy_report\/2019\/GBD_2017_Booklet.pdf Accessed: November 2020."},{"key":"bibr14-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31823c980f"},{"key":"bibr15-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000847"},{"key":"bibr16-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2016.04.006"},{"key":"bibr17-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4750-z"},{"key":"bibr18-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002007"},{"key":"bibr19-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000123"},{"key":"bibr20-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644"},{"issue":"29","key":"bibr21-08850666211054444","first-page":"530","volume":"2003","author":"Levy MM","year":"2001","journal-title":"Intensive Care Med"},{"key":"bibr22-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20198595"},{"key":"bibr23-08850666211054444","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20160068"},{"key":"bibr24-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001864"},{"key":"bibr25-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001862"},{"key":"bibr26-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160642"},{"key":"bibr27-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001536"},{"key":"bibr28-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.12.035"},{"key":"bibr29-08850666211054444","doi-asserted-by":"publisher","DOI":"10.17265\/2159-5313\/2016.09.003"},{"key":"bibr30-08850666211054444","unstructured":"Organizaci\u00f3n Panamericana de la Salud. Cap\u00edtulo 4: Condiciones de salud y sus tendencias. Mortalidad en las Am\u00e9ricas. En: Salud en las Am\u00e9ricas: edici\u00f3n de 2012. Volumen I-Regional. Washington, DC: OPS; 2012:111-124. Available at: https:\/\/www.paho.org\/salud-en-las-americas-2012\/dmdocuments\/hia-2012-chapter-4.pdf. Accessed November 202."},{"key":"bibr31-08850666211054444","unstructured":"The Global Health Observatory. World health Organization. Available at: https:\/\/www.who.int\/data\/gho\/data\/indicators\/indicator-details\/GHO\/medical-doctors-(per-10-000-population) Accessed November 2020."},{"issue":"3","key":"bibr32-08850666211054444","first-page":"S135","volume":"117","author":"Jabornisky R","year":"2019","journal-title":"Arch Argent Pediatr"},{"key":"bibr33-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000002043"},{"key":"bibr34-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.2352"},{"key":"bibr35-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-5021-8"},{"key":"bibr36-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31828a2bbd"},{"key":"bibr37-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2019.05.018"},{"key":"bibr38-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2019.07.007"},{"key":"bibr39-08850666211054444","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20170029"},{"key":"bibr40-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001741"},{"key":"bibr41-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.08.001"},{"key":"bibr42-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1987"},{"key":"bibr43-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.138362"},{"key":"bibr44-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000350"},{"key":"bibr45-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000433"},{"key":"bibr46-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4920-z"},{"key":"bibr47-08850666211054444","doi-asserted-by":"publisher","DOI":"10.32641\/rchped.v91i1.1205"},{"key":"bibr48-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1979"},{"key":"bibr49-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001222"},{"key":"bibr50-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1101549"},{"key":"bibr51-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002337"},{"key":"bibr52-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1177\/08850666211004453"},{"key":"bibr53-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002365"},{"key":"bibr54-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001260"},{"key":"bibr55-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000509"},{"key":"bibr56-08850666211054444","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001380"}],"container-title":["Journal of Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666211054444","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08850666211054444","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666211054444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:57:00Z","timestamp":1777503420000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08850666211054444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1177\/08850666211054444"],"URL":"https:\/\/doi.org\/10.1177\/08850666211054444","relation":{},"ISSN":["0885-0666","1525-1489"],"issn-type":[{"value":"0885-0666","type":"print"},{"value":"1525-1489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]}}}