{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:08:45Z","timestamp":1787065725729,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Introduction: Despite its widespread use, there is a paucity of data to guide the optimal use of arginine vasopressin (AVP) in critically ill patients with septic shock. Methods: This multicenter retrospective cohort study conducted in critically ill adults sought to evaluate the role of catecholamine requirements and timing on responsiveness to AVP. Responsiveness was defined as both a decrease in \u2265 50% of catecholamine requirements and no decrease in mean arterial pressure (MAP) at 4\u2005hours post-AVP initiation. Primary outcomes of interest included the proportion of patients who started AVP within 4\u2005hours after starting catecholamine therapy, as well as baseline norepinephrine (NE) equivalents (&lt; 15, 15-39, or \u2265 40 mcg\/min). Multivariate analyses and logistic regression were performed to identify other factors associated with AVP responsiveness. Results: There were 300 patients included in this study, with 74 patients being responders and 226 being non-responders. There was no significant difference in the number of patients who received AVP within 4\u2005hours from catecholamine initiation between responders and non-responders (35% vs. 42%, P\u2009=\u20090.29). There were more patients in the non-responder group requiring \u2265 40\u2005mcg\/min of NE equivalents at AVP initiation (30% vs. 16%, P\u2009=\u20090.023). Stress dose steroid use was less common in responders (35% vs. 52%, P\u2009=\u20090.011), which was consistent with logistic regression analysis (OR 0.56, 95% 0.32-0.98, P\u2009=\u20090.044). Clinical outcomes between responders and non-responders were similar, apart from ICU (5.4% vs. 19.5%) and hospital (5.4% vs. 20.4%) mortality being lower in responders (P\u2009=\u20090.0032 and P\u2009=\u20090.0002, respectively). Conclusion: Shorter times to AVP initiation was not associated with responsiveness at 4\u2005hours post-catecholamine initiation, although non-responders tended to require higher doses of NE equivalents at time of AVP initiation. Concomitant corticosteroids were associated with a lower likelihood of AVP responsiveness.<\/jats:p>","DOI":"10.1177\/08850666221081836","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T09:22:59Z","timestamp":1645608179000},"page":"1512-1519","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Influence of Timing and Catecholamine Requirements on Vasopressin Responsiveness in Critically ill Patients with Septic Shock"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6180-8351","authenticated-orcid":false,"given":"Nicholas D.","family":"Jakowenko","sequence":"first","affiliation":[{"name":"Banner University Medical Center \u2013 Tucson, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Murata","sequence":"additional","affiliation":[{"name":"Banner University Medical Center \u2013 Tucson, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Kopp","sequence":"additional","affiliation":[{"name":"Banner University Medical Center \u2013 Tucson, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-9921","authenticated-orcid":false,"given":"Brian L.","family":"Erstad","sequence":"additional","affiliation":[{"name":"University of Arizona College of Pharmacy, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"bibr1-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02950-2"},{"key":"bibr2-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005337"},{"key":"bibr3-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000206466.56669.BE"},{"key":"bibr4-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.4528"},{"key":"bibr5-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.03.005"},{"key":"bibr6-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067373"},{"key":"bibr7-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000520"},{"key":"bibr8-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0532-y"},{"key":"bibr9-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1177\/1060028016656384"},{"key":"bibr10-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001086"},{"key":"bibr11-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1177\/0885066620977181"},{"key":"bibr12-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000212"},{"key":"bibr13-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020901521"},{"key":"bibr14-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.728840"},{"key":"bibr15-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1177\/1060028017729480"},{"key":"bibr16-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-018-0379-5"},{"key":"bibr17-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10485"},{"key":"bibr18-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1177\/0885066617725255"},{"key":"bibr19-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2105"},{"key":"bibr20-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.06.016"},{"key":"bibr21-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1177\/1060028016669163"},{"key":"bibr22-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1186\/cc12794"},{"key":"bibr23-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1687-x"},{"key":"bibr24-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181961ace"},{"key":"bibr25-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2199"},{"key":"bibr26-08850666221081836","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001609"}],"container-title":["Journal of Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666221081836","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08850666221081836","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666221081836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:57:10Z","timestamp":1777503430000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08850666221081836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,23]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1177\/08850666221081836"],"URL":"https:\/\/doi.org\/10.1177\/08850666221081836","relation":{},"ISSN":["0885-0666","1525-1489"],"issn-type":[{"value":"0885-0666","type":"print"},{"value":"1525-1489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,23]]}}}