{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:05:07Z","timestamp":1785899107797,"version":"3.56.0"},"reference-count":55,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100019289","name":"University of Kansas School of Medicine-Wichita","doi-asserted-by":"crossref","award":["Dean's Level One Grant Award"],"award-info":[{"award-number":["Dean's Level One Grant Award"]}],"id":[{"id":"10.13039\/100019289","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:p>Introduction: Mortality estimates from sepsis and septic shock ranged from 18% to 35% and 40% to 60%, respectively, prior to 2014. Sepsis patients who experience subsequent cardiovascular events have increased mortality; however, data are limited among septic shock patients. This study reports in-hospital mortality, incident cardiovascular events, and cardiovascular procedures among sepsis patients with and without subsequent septic shock. Methods: Patients with a primary diagnosis of sepsis with and without a secondary diagnosis of septic shock were identified from the 2016 and 2017 National Readmissions Database. These patients were then evaluated for the occurrence of cardiovascular events and procedures. Results: A total of 2,127,137 patients were included in the study, with a mean age of 66 years. Twenty percent of patients (n\u2009=\u2009420,135) developed subsequent septic shock. In-hospital mortality among patients with a primary diagnosis of sepsis was 5.3%, and it was 31.2% for those with subsequent septic shock. Notable cardiovascular events occurring among sepsis patients with and without subsequent septic shock, respectively, included: acute kidney injury (65.1% vs. 32.8%, P\u2009&lt; .0001), acute systolic heart failure (9.8% vs. 5.1%, P &lt; .0001), NSTEMI (8.8% vs. 3.2%, P &lt; .0001), and ischemic stroke (2.3% vs. 0.9%, P &lt; .0001). Similarly, the most common cardiovascular procedures between the two groups were: percutaneous coronary intervention (0.37% vs. 0.20%, P &lt; .0001), intra-aortic balloon pump (0.19% vs. 0.02%, P &lt; .0001), and extracorporeal membrane oxygenation (0.18% vs. 0.01%, P &lt; .0001). Conclusions: Sepsis with subsequent septic shock is associated with an increased frequency of in-hospital cardiovascular events and procedures.<\/jats:p>","DOI":"10.1177\/08850666221083644","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T03:20:14Z","timestamp":1646277614000},"page":"1528-1534","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Sepsis, Septic Shock, and Differences in Cardiovascular Event Occurrence"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5621-0064","authenticated-orcid":false,"given":"Grace E.","family":"Falk","sequence":"first","affiliation":[{"name":"Medical Students, University of Kansas School of Medicine-Wichita, Wichita, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerad","family":"Rogers","sequence":"additional","affiliation":[{"name":"Medical Students, University of Kansas School of Medicine-Wichita, Wichita, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuqiang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Population Health, University of Kansas School of Medicine-Wichita, Wichita, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Ablah","sequence":"additional","affiliation":[{"name":"Department of Population Health, University of Kansas School of Medicine-Wichita, Wichita, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrettin","family":"Okut","sequence":"additional","affiliation":[{"name":"Department of Population Health, University of Kansas School of Medicine-Wichita, Wichita, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6163-9789","authenticated-orcid":false,"given":"Mohinder R.","family":"Vindhyal","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Kansas University Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"bibr1-08850666221083644","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000659"},{"key":"bibr2-08850666221083644","unstructured":"CDC. 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