{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:29:57Z","timestamp":1791487797287,"version":"4.3.4"},"reference-count":59,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Acute physical function outcomes in ICU survivors of COVID-19 pneumonia has received little attention. Critically ill patients with COVID-19 infection who require invasive mechanical ventilation may undergo greater exposure to some risk factors for ICU-acquired weakness (ICUAW).\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To determine incidence and factors associated with ICUAW at ICU discharge and gait dependence at hospital discharge in mechanically ventilated patients with COVID-19 pneumonia.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Single-centre, prospective cohort study conducted at a tertiary hospital in Madrid, Spain. We evaluated ICUAW with the Medical Research Council Summary Score (MRC-SS). Gait dependence was assessed with the Functional Status Score for the ICU (FSS-ICU) walking subscale.\n                    <jats:bold>Results:<\/jats:bold>\n                    During the pandemic second wave, between 27 July and 15 December, 2020, 70 patients were enrolled. ICUAW incidence was 65.7% and 31.4% at ICU discharge and hospital discharge, respectively. Gait dependence at hospital discharge was observed in 66 (54.3%) patients, including 9 (37.5%) without weakness at ICU discharge. In univariate analysis, ICUAW was associated with the use of neuromuscular blockers (crude odds ratio [OR] 9.059; p\u2009=\u20090.01) and duration of mechanical ventilation (OR 1.201; p\u2009=\u20090.001), but not with the duration of neuromuscular blockade (OR 1.145, p\u2009=\u20090.052). There was no difference in corticosteroid use between patients with and without weakness. Associations with gait dependence were lower MRC-SS at ICU discharge (OR 0.943; p\u2009=\u20090.015), older age (OR 1.126; p\u2009=\u20090.001), greater Charlson Comorbidity Index (OR 1.606; p\u2009=\u20090.011), longer duration of mechanical ventilation (OR 1.128; p\u2009=\u20090.001) and longer duration of neuromuscular blockade (OR 1.150; p\u2009=\u20090.029).\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    In critically ill COVID-19 patients, the incidence of ICUAW and acute gait dependence were high. Our study identifies factors influencing both outcomes. Future studies should investigate optimal COVID-19 ARDS management and impact of dyspnea on acute functional outcomes of COVID-19 ICU survivors.\n                  <\/jats:p>","DOI":"10.1177\/08850666221100498","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T17:12:00Z","timestamp":1652893920000},"page":"1005-1014","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["Intensive Care Unit- Acquired Weakness and Hospital Functional Mobility Outcomes Following Invasive Mechanical Ventilation in Patients with COVID-19: A Single-Centre Prospective Cohort Study"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3414-6502","authenticated-orcid":false,"given":"Maria N.","family":"N\u00fa\u00f1ez-Seisdedos","sequence":"first","affiliation":[{"name":"Physiotherapy Department, Ram\u00f3n y Cajal University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-9200","authenticated-orcid":false,"given":"Irene","family":"L\u00e1zaro-Navas","sequence":"additional","affiliation":[{"name":"Physiotherapy Department, Ram\u00f3n y Cajal University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"L\u00f3pez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Physiotherapy Department, Ram\u00f3n y Cajal University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"L\u00f3pez-Aguilera","sequence":"additional","affiliation":[{"name":"Nursing Department, Ram\u00f3n y Cajal University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0994"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105924"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30459-8"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03164-2"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17023"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70178-8"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2174-z"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002763"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002208"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05927-5"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201312-2257OC"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-019-0404-2"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011802"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000040"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020163"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzy158"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004467"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-016-0187-8"},{"key":"e_1_3_4_20_2","unstructured":"Weekly operational update on COVID-19\u20138 March 2021. https:\/\/www.who.int\/publications\/m\/item\/weekly-operational-update-on-covid-19-8-march-2021 (Accessed December 5 2021)"},{"key":"e_1_3_4_21_2","article-title":"COVID-19: the challenge of patient rehabilitation after intensive care","volume":"6","author":"Thornton J","year":"2020","unstructured":"Thornton J. 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