{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:06:56Z","timestamp":1781086016775,"version":"3.54.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Previous studies analyzing neuromuscular blocking agents (NMBAs) in acute respiratory distress syndrome (ARDS) have evaluated the benefit of cisatracurium with conflicting results, and data evaluating other NMBAs remains limited. The objective of this study was to compare the efficacy and safety of cisatracurium to vecuronium in ARDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      A single-center, retrospective, propensity matched review of patients who received cisatracurium or vecuronium continuous infusions between October 1, 2017 and June 30, 2020 for ARDS was conducted. The primary endpoint was duration of mechanical ventilation. Secondary endpoints included change in PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      ratio at 48 h, intensive care unit (ICU) and hospital mortality, and ICU and hospital length of stay (LOS). Safety endpoints included newly developed myopathy, presence of bradycardia or hypotension, and newly developed barotrauma or volutrauma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-nine patients were included in each group. There was no statistically significant difference in the primary endpoint of ventilator days between cisatracurium and vecuronium groups (mean 15.9 vs. 20.5 days respectively; p\u2009=\u2009.2). No statistically significant differences were found in secondary endpoints of ICU mortality (51.7% vs. 51.7%) or length of stay (18.7 vs. 23.9 days, p\u2009 =\u2009 .19), hospital mortality (51.7% vs. 55.2%, p\u2009 =\u2009 .79) or length of stay (22 vs. 30.6 days, p\u2009 =\u2009 .08), or mean change in PaO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      (29.8 vs. 36.6; p\u2009 =\u2009 .74). Statistically significant differences were not observed in safety endpoints of myopathy (37.9% vs. 37.9%), barotrauma or volutrauma (13.8% vs. 3.5%; p\u2009=\u2009.16), bradycardia (31% vs. 13.8%; p\u2009=\u2009.12), or hypotension (96.6% vs. 82.8%; p\u2009=\u2009.08)\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No significant differences were seen in efficacy or safety endpoints between cisatracurium or vecuronium groups, suggesting that vecuronium may be a safe alternative agent for neuromuscular blockade in ARDS. Results of this analysis warrant confirmation in a larger, randomized study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666221113504","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T23:45:07Z","timestamp":1657669507000},"page":"188-195","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and Safety of Cisatracurium Compared to Vecuronium for Neuromuscular Blockade in Acute Respiratory Distress Syndrome"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7610-2562","authenticated-orcid":false,"given":"Priya","family":"Vallabh","sequence":"first","affiliation":[{"name":"Department of Pharmacy, UMass Memorial Medical Center, Worcester, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, UMass Memorial Medical Center, Worcester, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystina","family":"Ahern","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, UMass Memorial Medical Center, Worcester, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"bibr1-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"bibr2-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214103"},{"key":"bibr3-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062200"},{"key":"bibr4-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1007136"},{"key":"bibr5-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2817-8"},{"key":"bibr6-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000248331.36982.28"},{"key":"bibr7-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005372"},{"key":"bibr8-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002027"},{"key":"bibr9-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.6.1627"},{"key":"bibr10-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.5.8630621"},{"key":"bibr11-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181b6e64c"},{"key":"bibr12-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-001-1112-6"},{"key":"bibr13-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-010-0010-6"},{"key":"bibr14-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1007\/s001340101009"},{"key":"bibr15-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1186\/2110-5820-2-43"},{"key":"bibr16-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901686"},{"key":"bibr17-08850666221113504","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05102"},{"key":"bibr18-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201706-1132OC"},{"key":"bibr19-08850666221113504","volume-title":"Goodman and Gilman\u2019s: The Pharmacological Basis of Therapeutics, 12e","author":"Hibbs RE","year":"2015"},{"key":"bibr20-08850666221113504","volume-title":"Applied Therapeutics: The Clinical Use of Drugs","author":"Koda-Kimble MA","year":"2013","edition":"10"},{"key":"bibr21-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2134"},{"key":"bibr22-08850666221113504","volume-title":"Acute Respiratory Distress Syndrome","author":"Diamond M","year":"2021"},{"key":"bibr23-08850666221113504","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04716"},{"key":"bibr24-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199208203270804"},{"key":"bibr25-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30370-2"},{"key":"bibr26-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30079-5"},{"key":"bibr27-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03240-7"},{"key":"bibr28-08850666221113504","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50674"},{"key":"bibr29-08850666221113504","unstructured":"tCisatracurium. Lexi-Drugs. Hudson, OH: Lexicomp, 2022. http:\/\/online.lexi.com\/. Updated April 19, 2022. Accessed April 22, 2022."},{"key":"bibr30-08850666221113504","unstructured":"Vecuronium. Lexi-Drugs. Hudson, OH: Lexicomp, 2022. http:\/\/online.lexi.com\/. Updated April 19, 2022. Accessed April 22, 2022."},{"key":"bibr31-08850666221113504","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-6-15"}],"container-title":["Journal of Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666221113504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08850666221113504","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666221113504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:57:19Z","timestamp":1777503439000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08850666221113504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,12]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1177\/08850666221113504"],"URL":"https:\/\/doi.org\/10.1177\/08850666221113504","relation":{},"ISSN":["0885-0666","1525-1489"],"issn-type":[{"value":"0885-0666","type":"print"},{"value":"1525-1489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,12]]}}}