{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:59:32Z","timestamp":1791921572549,"version":"4.3.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Background: The initial hemodynamic goal during septic shock resuscitation is to achieve a mean arterial pressure (MAP) above 65\u2005mm Hg, although this does not assure a normal tissue perfusion. Capillary refill time (CRT), a marker of skin blood flow, has been validated as a marker of the reperfusion process. The aim of the study was to explore the relationship between MAP and CRT in patients in septic shock. Methods: We systematically reviewed studies which reported CRT and MAP in septic shock patients. Authors of eligible studies were asked to provide necessary data for performing a meta-correlation of Spearman's rank correlation coefficients. Subgroup analyses were performed, including studies of good quality and studies with higher\/lower norepinephrine doses. Results: We identified 10 studies, comprising 917 patients. There were 5 studies considered to be of good quality. A meta-correlation showed a statistically significant but poor negative correlation between MAP and CRT ( R\u2009=\u2009\u22120.158, range \u22120.221 to \u22120.093, P\u2009&lt;\u2009.001, I2\u2009=\u20090.0%). Subgroup analysis of best-quality studies gave similar results ( R\u2009=\u2009\u22120.201, range \u22120.282 to \u22120.116, P\u2009&lt;\u2009.001, I2\u2009=\u20090.0%). In subanalysis concerning norepinephrine doses, no significant correlations were found. Conclusions: In patients with septic shock, there is poor inverse correlation between MAP and CRT. MAP\u2009&gt;\u200965\u2005mm Hg does not guarantee normalization of CRT. Registration code: PROSPERO: CRD42022355996. Registered on 5 September 2022.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666231168038","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T02:17:00Z","timestamp":1681265820000},"page":"838-846","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Correlation Between Mean Arterial Pressure and Capillary Refill Time in Patients with Septic Shock: A Systematic Review and Meta-analysis"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1740-4322","authenticated-orcid":false,"given":"Zbigniew","family":"Putowski","sequence":"first","affiliation":[{"name":"Centre for Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Go\u0142dyn","sequence":"additional","affiliation":[{"name":"Department 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Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1997-6893","authenticated-orcid":false,"given":"Eduardo","family":"Kattan","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, 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