{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:17:49Z","timestamp":1777853869391,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG053582"],"award-info":[{"award-number":["R01AG053582"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Society of Academic Associations of Anesthesiology & Perioperative Medicine"},{"DOI":"10.13039\/100005831","name":"Foundation for Anesthesia Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005831","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM120484"],"award-info":[{"award-number":["GM120484"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL111111"],"award-info":[{"award-number":["HL111111"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We investigated the association of age, sex, race, and insurance status on antipsychotic medication use among intensive care unit (ICU) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Retrospective study of adults admitted to ICUs at a tertiary academic center. Patient characteristics, hospital course, and medication (olanzapine, quetiapine, and haloperidol) data were collected. Logistic regression models evaluated the independent association of age, sex, race, and insurance status on the use of each antipsychotic, adjusting for prespecified covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 27,137 encounters identified, 6191 (22.8%) received antipsychotics. Age was significantly associated with the odds of receiving olanzapine ( P\u2009&lt;\u2009.001), quetiapine ( P\u2009=\u2009.001), and haloperidol ( P\u2009=\u2009.0046). Male sex and public insurance status were associated with increased odds of receiving antipsychotics olanzapine, quetiapine, and haloperidol (Male vs Female: OR 1.13, 95% CI [1.04, 1.24], P\u2009=\u2009.0005; OR 1.22, 95% CI [1.10, 1.34], P\u2009=\u2009.0001; OR 1.28, 95% CI [1.17, 1.40], P\u2009&lt;\u2009.0001, respectively; public insurance vs private insurance: OR 1.32, 95% CI [1.20, 1.46], P\u2009&lt;\u2009.0001; OR 1.21, 95% CI [1.09, 1.34], P\u2009=\u2009.0004; OR 1.15, 95% CI [1.04, 1.27], P\u2009=\u2009.0058, respectively). Black race was also associated with a decreased odds of receiving all antipsychotics (olanzapine ( P\u2009=\u2009.0177), quetiapine ( P\u2009=\u2009.004), haloperidol ( P\u2009=\u2009.0041)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Age, sex, race, and insurance status were associated with the use of all antipsychotic medications investigated, highlighting the importance of investigating the potential impact of these prescribing decisions on patient outcomes across diverse populations. Recognizing how nonmodifiable patient factors have the potential to influence prescribing practices may be considered an important factor toward optimizing medication regimens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666231198030","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T03:23:20Z","timestamp":1693365800000},"page":"176-182","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Association of Nonmodifiable Patient Factors on Antipsychotic Medication use in the Intensive Care Unit"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9433-249X","authenticated-orcid":false,"given":"Jennifer","family":"Connell","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Medicine, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany","family":"McCann","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoke","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew S.","family":"Shotwell","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-4696","authenticated-orcid":false,"given":"Christina S.","family":"Boncyk","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"key":"bibr1-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1177\/1090198121997812"},{"issue":"2","key":"bibr2-08850666231198030","first-page":"19","volume":"129","author":"Braveman P","journal-title":"Public Health Rep Wash DC 1974"},{"key":"bibr3-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2019.07.013"},{"key":"bibr4-08850666231198030","doi-asserted-by":"publisher","DOI":"10.7326\/M17-2441"},{"key":"bibr5-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1808217"},{"key":"bibr6-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005365"},{"key":"bibr7-08850666231198030","volume":"9","author":"Burry L","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr8-08850666231198030","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.16m10976"},{"key":"bibr9-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2016.1201475"},{"key":"bibr10-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30177-9"},{"key":"bibr11-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1186\/cc11342"},{"key":"bibr12-08850666231198030","author":"Casol M","year":"2021","journal-title":"J Am Psychiatr Nurses Assoc."},{"key":"bibr13-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15418"},{"key":"bibr14-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2016.12.005"},{"key":"bibr15-08850666231198030","unstructured":"Predicting mortality in the intensive care unit: a comparison of the University Health Consortium expected probability of mortality and the Mortality Prediction Model III - PubMed. Accessed May 24, 2022. https:\/\/pubmed-ncbi-nlm-nih-gov.proxy.library.vanderbilt.edu\/27217959\/"},{"key":"bibr16-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.22.2983"},{"key":"bibr17-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.21.2703"},{"key":"bibr18-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14076"},{"key":"bibr19-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.03.030"},{"key":"bibr20-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1557-1"},{"key":"bibr21-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.88.5.770"},{"key":"bibr22-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1186\/s12910-017-0179-8"},{"key":"bibr23-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2022.02.003"},{"key":"bibr24-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.03.027"},{"key":"bibr25-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.149.3.379"},{"key":"bibr26-08850666231198030","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0518g"},{"key":"bibr27-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.071112"},{"key":"bibr28-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1186\/cc10323"},{"key":"bibr29-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000069347.78151.50"},{"key":"bibr30-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005469"},{"key":"bibr31-08850666231198030","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7103e1"},{"key":"bibr32-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1089\/heq.2021.0130"},{"key":"bibr33-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181c8fd58"},{"key":"bibr34-08850666231198030","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318206b3af"}],"container-title":["Journal of Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666231198030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08850666231198030","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666231198030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:57:46Z","timestamp":1777503466000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08850666231198030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,30]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1177\/08850666231198030"],"URL":"https:\/\/doi.org\/10.1177\/08850666231198030","relation":{},"ISSN":["0885-0666","1525-1489"],"issn-type":[{"value":"0885-0666","type":"print"},{"value":"1525-1489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,30]]}}}